| Japanese |
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| Title | 肥大型心筋症における123I - MIBG心筋シンチグラフィの臨床的有用性についての検討 |
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| Subtitle | 原著 |
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| Authors | 井門明*, 長谷部直幸*, 中村秀樹*, 大井伸治*, 辻史郎*, 横山亜由美*, 木戸伸介*, 石井良直*, 川村祐一郎*, 山下裕久*, 菊池健次郎*, 山本和香子**, 秀毛範至**, 油野民雄** |
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| Organization | *旭川医科大学第一内科, **放射線科 |
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| Journal | 核医学 |
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| Volume | 34 |
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| Number | 9 |
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| Page | 807-814 |
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| Year/Month | 1997/9 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」肥大型心筋症(HCM)における心臓交感神経系の異常を, 123I-MIBG心筋シンチグラフィと各種臨床検査指標との関連から検討した. 健常対照群(8例)に比しHCM群(50例)では, いずれも有意にMIBGの心縦隔比(H/M)は低く, washout rate(WR)は高かった. H/Mは血漿ノルエピネフリン値, 心筋壁厚, 左室心筋量, LVEDPとの間にいずれも有意な負の相関を認め, WRは上記指標といずれも有意に正相関した. 一方Holter心電図のスペクトル解析から求めたLF/HF比は, H/Mと正相関, WRとは負の相関を示した. さらに, HCM群を自覚症状・心房細動または発作性心房細動(PAf)の有無で2群に分けると, 有自覚症状群で有意にH/Mは低値であり, PAf群で有意にWRが亢進していた. HCMにおける組織変性が123I-MIBGの集積や動態の異常を惹起していると考えられ, 123I-MIBGのH/MやWRは各種臨床検査指標からみたHCMの病態の重症度および病型の相違を反映し, さらに詳細なHCMの病態把握に寄与する指標となり得る可能性が示唆された. |
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| Practice | 臨床医学：一般 |
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| Keywords | 123I-metaiodobenzylguanidine(MIBG), Hypertrophic cardiomyopathy, Myocardial sympathetic function. |
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| English |
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| Title | Clinical Significance of 123I - MIBG Myocardial Scintigraphy in Patients with Hypertrophic Cardiomyopathy |
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| Subtitle | Original Articles |
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| Authors | Akira IDO*, Naoyuki HASEBE*, Hideki NAKAMURA*, Shinji OHI*, Shiro TSUJI*, Ayumi YOKOYAMA*, Shinsuke KIDO*, Yoshinao ISHII*, Yuichiro KAWAMURA*, Hirohisa YAMASHITA*, Kenjiro KIKUCHI*, Wakako YAMAMOTO**, Noriyuki SHUUKE**, Tamio ABURANO** |
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| Authors(kana) | |
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| Organization | *First Department of Internal Medicine, **Department of Radiology, Asahikawa Medical College |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 34 |
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| Number | 9 |
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| Page | 807-814 |
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| Year/Month | 1997/9 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]We studied the abnormality of myocardial sympathetic nervous system in patients with hypertrophic cardiomyopathy using 123I-metaiodobenzylguanidine(MIBG)myocardial scintigraphy in comparison with the parameters of other clinical examinations. In 50 patients with HCM, the heart to mediastinum 123I-MIBG uptake ratio(H/M)was significantly low and washout rate(WR)of 123I-MIBG was significantly high respectively compared with normal subjects(n=8). H/M was negatively correlated with serum norepinephrine level, wall thickness of left ventricle, left ventricular mass index, left ventricular end diastolic pressure respectively, and WR was positively correlated with those parameters respectively. On the other hand, LF/HF calculated by spectral analysis in holter electrocardiogram was positively correlated with H/M, and negatively correlated with WR. In HCM, H/M in patients with subjective symptoms was significantly lower than that without subjective symptoms, and WR in patients with paroxysmal atrial fibrillation was significantly higher than that without paroxysmal atrial fibrillation. This study revealed that H/M and WR reflected the severity and the difference of disease type in HCM. In conclusion, 123I-MIBG contributes to evaluating more details in diagnosis and pathophysiology of HCM. |
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| Practice | Clinical medicine |
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| Keywords | 123I-metaiodobenzylguanidine(MIBG), Hypertrophic cardiomyopathy, Myocardial sympathetic function. |
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