| Japanese |
|---|
| Title | 糖尿病患者における123I - MIBGの肺集積についての検討 |
|---|
| Subtitle | 原著 |
|---|
| Authors | 長町茂樹*, 陣之内正史*, Leo G. FLORES II*, 大西隆*, 二見繁美*, 中原浩*, 田村正三*, 渡邊克司*, 黒瀬健**, 松倉茂** |
|---|
| Authors(kana) | |
|---|
| Organization | *宮崎医科大学放射線医学教室, **第三内科 |
|---|
| Journal | 核医学 |
|---|
| Volume | 34 |
|---|
| Number | 9 |
|---|
| Page | 797-805 |
|---|
| Year/Month | 1997/9 |
|---|
| Article | 原著 |
|---|
| Publisher | 日本核医学会 |
|---|
| Abstract | 「要旨」糖尿病患者56名を対象に123I-MIBGの肺集積について検討した. 糖尿病症例を無症候性心筋虚血(SMI)の有無と安静時心電図RR間隔の変動係数より求めた心臓自律神経障害(AN)の有無とにより4つの群に分類した. それぞれの群について123I-MIBG胸部正面planar像より求めた肺/縦隔比(L/M), 心/縦隔比(H/M)およびそれぞれ早期, 後期像から算出した肺洗い出し率(%WR-L), 心筋洗い出し率(%WR-H)を比較した. 合併症を有する糖尿病群では対照群と比較し有意にH/Mが低く%WR-Hが高かった. また, 糖尿病群間ではSMI(+)AN(+)群, SMI(+)AN(-)群, SMI(-)AN(+)群, SMI(-)AN(-)群の順にH/Mが低値および%WR-Hが高値を示した. L/Mについては, 糖尿病群でいずれもコントロール群と比較して有意に高値を示した. 糖尿病群間では早期像でSMI(-)AN(+)群がSMI(+)AN(-)群およびSMI(-)AN(-)群と比較し有意に高値を示したほかは有意な差は認められなかった. %WR-Lも糖尿病群ではコントロール群と比べ有意に高値を示したが, 糖尿病群間では有意な差はみられなかった. 糖尿病患者では心集積に直接的には影響されない肺への123I-MIBGの集積異常が存在することが判明し糖尿病重症度, 特に肺血管内皮障害との関連が示唆された. |
|---|
| Practice | 臨床医学：一般 |
|---|
| Keywords | 123I-MIBG, Diabetes mellitus, Lung uptake. |
|---|
| English |
|---|
| Title | 123I - MIBG Lung Uptake in Patients with Diabetes Mellitus |
|---|
| Subtitle | Original Articles |
|---|
| Authors | Shigeki NAGAMACHI*, Seishi JINNOUCHI*, Leo G. FLORES II*, Takashi OHNISHI*, Shigemi FUTAMI*, Hiroshi NAKAHARA*, Shozo TAMURA*, Katsushi WATANABE*, Takeshi KUROSE**, Shigeru MATSUKURA** |
|---|
| Authors(kana) | |
|---|
| Organization | *Department of Radiology, Miyazaki Medical College, *Third Department of Internal Medicine, Miyazaki Medical College |
|---|
| Journal | The Japanese Journal of nuclear medicine |
|---|
| Volume | 34 |
|---|
| Number | 9 |
|---|
| Page | 797-805 |
|---|
| Year/Month | 1997/9 |
|---|
| Article | Original article |
|---|
| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
|---|
| Abstract | [Summary]The purpose of this study is to clarify the relationship between 123I-MIBG lung uptake and silent myocardial ischemia(SMI), cardiac autonomic neuropathy(AN)or clinical characteristics. For the quantitative analysis, lung to upper mediastinum uptake ratio(LIM)and heart to upper mediastinum uptake ratio(H/M)were obtained from chest planar image. In addition, both lung washout ratio(%WR-L)and heart washout ratio(%WR-H)were calculated from early and delayed images. Each indices were compared in both diabetic and control groups. Mean values of H/M in diabetes with complication were significantly lower than those of control group. Particularly, AN(+)SMI(+)group showed lowest value. Similarly, mean values of %WR-H in diabetes with complication were significantly higher than those of control group and AN(+)SMI(+)group showed highest value. Although mean value of L/M in each diabetic group was significantly higher than that of control group, there was no statistical significance among each diabetes except AN(+)SMI(-)group on early image. Mean value of 90WR-L in AN(+)or SMI(+)group was also significantly higher than that of control group, but there was no statistical significance among each diabetic group. The current study suggested that high pulmonary 123I-MIBG uptake in diabetes was independent of the complication of SMI or AN. Pulmonary endothelial dysfunction related with severity of diabetes mellitus was considered to be the most important factor. |
|---|
| Practice | Clinical medicine |
|---|
| Keywords | 123I-MIBG, Diabetes mellitus, Lung uptake. |
|---|