| Japanese |
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| Title | 123I - BMIPP心筋無集積とI型CD36欠損がみられた肥大型心筋症について |
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| Subtitle | 症例報告 |
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| Authors | 渡辺賢一*, 宮島静一**, 草野頼子**, 田辺直仁**, 広川陽一*** |
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| Authors(kana) | |
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| Organization | *新潟薬科大学臨床薬理学, **燕労災病院循環器内科, ***新潟三之町病院内科 |
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| Journal | 核医学 |
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| Volume | 34 |
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| Number | 7 |
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| Page | 481-486 |
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| Year/Month | 1997/7 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」症例は57歳男性で, 胸部圧迫感と息切れを主訴として来院した. 心エコー図, 左室造影, 左心室生検像などから, 家族性拡張相肥大型心筋症(HCM)と診断された. 201Tl心筋シンチグラムでは心室中隔部の集積増加がみられたが, 123I-BMIPPの心筋集積はみられなかった. CD36は長鎖脂肪酸受容体や酸化LDL受容体として脂肪酸代謝や動脈硬化との関連が注目されているが, 本症例はI型CD36欠損がみられた. CD36欠損, 特に単球と血小板ともに欠損するI型CD36欠損が123I-BMIPP心筋無集積の一因子と思われる遺伝性HCM例を報告した. 「I. はじめに」123I-β-methyl-p-iodophenylpentadecanoic acid(BMIPP)は201TlCl(Tl)などの心筋血流画像では得られない脂肪酸代謝異常を検出でき, 虚血性心疾患や心筋疾患に臨床応用されている. |
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| Practice | 臨床医学：一般 |
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| Keywords | 123I-BMIPP, CD36 deficiency, Hypertrophic cardiomyopathy, Long-chain fatty acid, Familial HCM. |
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| English |
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| Title | Hypertrophic Cardiomyopathy Showing No 123I - BMIPP Myocardial Accumulation with Type I CD36 Deficiency |
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| Subtitle | Case Report |
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| Authors | Kenichi WATANABE*, Seiichi MIYAJIMA**, Yoriko KUSANO**, Naohito TANABE**, Yoichi HIROKAWA*** |
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| Authors(kana) | |
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| Organization | *Clinical Pharmacology, Niigata College of Pharmacy, **Division of Cardiology, Tsubame Rosai Hospital, ***Division of Internal Medicine, Niigata Sannocho Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 34 |
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| Number | 7 |
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| Page | 481-486 |
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| Year/Month | 1997/7 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]A 57 years old male consulted our hospital in complaining chest oppression and short of breath. Familial and dilated phase hypertrophic cardiomyopathy(HCM)was detected by ECG, echocardiography, left ventriculography and left ventricular endomyocardial biopsy. 201Tl SPECT showed regional increased accumulation in the ventricular septum, however, no myocardial accumulation of 123I-β-methyl-p-iodophenylpentadecanoic acid(123I-BMIPP)was observed. We analyzed CD36 in this patient, and found he had type I CD36 deficiency. Myocardial uptake of long-chain fatty acids occurs via a specific transporter, which is homologous with human CD36. We hypothesize that CD36 deficiency, especially type I CD36 deficiency, might be one factor of no myocardial 123I-BMIPP uptake. |
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| Practice | Clinical medicine |
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| Keywords | 123I-BMIPP, CD36 deficiency, Hypertrophic cardiomyopathy, Long-chain fatty acid, Familial HCM. |
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