| Japanese |
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| Title | 99mTc - MAA SPECTによる肺血流分布容積の定量 : 健常人と慢性閉塞性肺疾患の比較 |
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| Subtitle | 原著 |
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| Authors | 内田耕*, 宮坂隆*, 中山浩之*, 清水邦彦*, 高橋秀樹**, 高野政明** |
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| Organization | *東邦大学医学部第二内科, **大森病院中央放射線RI診断部 |
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| Journal | 核医学 |
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| Volume | 34 |
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| Number | 7 |
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| Page | 465-470 |
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| Year/Month | 1997/7 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」慢性閉塞性肺疾患(COPD)18名, 健常成人男子41名に99mTC-MAA肺血流SPECTを行い, Application Visualization Systemを用いて肺血流分布容積を定量した. 1ボクセル当たり最も高い放射能を100%とし, 21〜100%を10%毎に8段階に分け, 各段階の放射能が分布する肺血流分布容積(PV)を求め, threshold 21%以上の領域全体の容積(TPV)に対する割合(PV/TPV)を求め, 健常群とCOPD群を比較した. 健常群のPVおよびPV/TPVはthresholdが31〜70%の領域でほぼ同一の値をとり, 71〜100%にかけては次第に減少した. 喫煙群と非喫煙群の間には有意差はみられなかった. COPD群のPVは31〜70%の領域で, 健常群にみられたプラトーはなく, 徐々に低下し, 61%以上では健常群に比して著しく減少した. COPD群のPVは41〜100%で健常群に比して有意に低値をとった. COPD群のPV/TPVは健常群と比較して, 21〜40%の領域では有意に高値を, 51%以上の領域では有意に低値をとり, 肺血流分布が低下した領域の割合が増加していた. COPDの肺血流障害の指標としては, thresholdが60%以上の領域の肺血流分布容積が有用と考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | Three-dimensional imaging, 99mTc-MAA, Quantitative analysis, Application visualization system, Voxel. |
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| English |
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| Title | Quantitative Evaluation of Pulmonary Perfusion Volume using 99mTc - MAA SPECT : A Comparison of COPD Patients and Healthy Volunteers |
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| Subtitle | Original Articles |
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| Authors | Kou UCHIDA*, Takashi MIYASAKA*, Hiroyuki NAKAYAMA*, Kunihiko SHIMIZU*, Hideki TAKAHASHI**, Masaaki TAKANO** |
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| Authors(kana) | |
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| Organization | *Second Department of Internal Medicine, Toho University School of Medicine, **Department of Radiology, Toho University Ohmori Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 34 |
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| Number | 7 |
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| Page | 465-470 |
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| Year/Month | 1997/7 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]99mTc-MAA pulmonary perfusion single-photon emission computed tomography was performed on 18 patients with chronic obstructive pulmonary disease(COPD)and 41 healthy male volunteers. We quantified the extent of pulmonary perfusion with the Application Visualization System. We measured the pulmonary perfusion volume(PV)at 8 threshold levels encompassing 10 percentage points each from 21-100%. We also calculated the ratio of perfusion volume to total perfusion volume(TPV)at each threshold. Pulmonary perfusion volume in healthy volunteers remained relatively constant at levels of 31-70% and decreased gradually at levels of 71-100%. There was no significant difference in perfusion volume between smokers and non-smokers. Perfusion volume in COPD patients gradually decreased at levels of 31-60% and markedly decreased at levels greater than 60%. Perfusion volume differed significantly between COPD patients and healthy volunteers at levels of 41-100%. The mean PV/TPV value of COPD patients was significantly higher than that of healthy volunteers at levels of 21-40%and significantly lower than that of healthy volunteers at levels of more than 50%. This finding demonstrates that lung volume at high levels of pulmonary perfusion is decreased in COPD patients. The pulmonary perfusion volume at levels of more than 60% is an efficient means of distinguishing COPD patients from healthy subjects. |
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| Practice | Clinical medicine |
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| Keywords | Three-dimensional imaging, 99mTc-MAA, Quantitative analysis, Application visualization system, Voxel. |
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