Japanese
Title99mTc - tetrofosminを用いた運動負荷時心筋摂取増加率による虚血性心疾患の評価
Subtitle原著
Authors堀安裕子*,†, 滝淳一*, 中嶋憲一*, 清水賢巳**, 利波紀久*
Authors(kana)
Organization*金沢大学医学部核医学教室, **第二内科, †現徳島大学医学部放射線医学教室
Journal核医学
Volume34
Number7
Page433-441
Year/Month1997/7
Article原著
Publisher日本核医学会
Abstract「要旨」99mTc-tetrofosminを用いて, 負荷時と安静時の心筋への集積を定量評価して単位投与あたりの摂取増加率を算出することにより, 冠動脈病変の検出が向上するか否かを検討した. 虚血性心疾患の関与が疑われ冠動脈造影が施行された21例および対照として5例に対し, 1日法で運動負荷・安静の順で99mTc-tetrofosmin心筋シンチグラフィを施行した. 負荷・安静時の投与量は約1:2とし, 投与量の正確な計測を行った. 撮像は投与後20分から開始した. 定量的評価として, circumferential profile解析からpolar map表示を行い. 単位投与あたりの心筋摂取増加率(%uptake increase)を算出した. 冠動脈造影の結果と比較したところ, 有意の冠動脈病変を有する患者のsensitivityは視覚的評価で60%, 定量的評価で90%であった. 病変を有した10例中5例では視覚的には指摘できなかった病変部位が心筋摂取増加率の算出で指摘可能であった. 心筋摂取増加率の算出の追加により冠動脈病変の検出が向上する可能性が示唆された.
Practice臨床医学：一般
Keywords99mTc-tetrofosmin, Myocardial SPECT, Ischemic heart disease, Percent uptake increase, Coronary flow reserve.
English
TitleEvaluation of Ischemic Heart Disease Using the Index of Relative 99mTc - Tetrofosmin Uptake Increase at Exercise
SubtitleOriginal Articles
AuthorsAyuko HORI*,#, Junichi TAKI*, Kenichi NAKAJIMA*, Masami SHIMIZU**, Norihisa TONAMI*
Authors(kana)
Organization*Department of Nuclear Medicine, **Second Department of Internal Medicine, Kanazawa University School of Medicine, #Department of Radiology, Tokushima University School of Medicine at present
JournalThe Japanese Journal of nuclear medicine
Volume34
Number7
Page433-441
Year/Month1997/7
ArticleOriginal article
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
Abstract[Summary]We calculated an increase of myocardial 99mTc-tetrofosmin uptake during exercise from resting condition, which was thought to reflect coronary flow reserve, and assessed whether this method enhanced the detection of coronary artery disease(CAD). Exercise myocardial SPECT was performed using 99mTc-tetrofosmin with one-day method(exercise-rest)in 26 patients. Twenty-one patients were suspected to have ischemic heart disease and 5 were control patients. A polar map was used to evaluate the increase in counts after exercise. The parameter of %uptake increase was obtained by the ratio of exercise and resting myocardial counts. The uptake was corrected for administration dose and time decay between the exercise and rest studies. The sensitivity for detecting patients with significant coronary stenosis by visual evaluation and %uptake increase map was 60% and 90%, respectively. In 5 patients, %uptake increase map detected stenosed coronary artery lesions that could not be detected by visual analysis. We concluded that the %uptake increase map combined with conventional SPECT images enhanced the detectability of coronary artery disease and the evaluation of the degree of coronary flow reserve.
PracticeClinical medicine
Keywords99mTc-tetrofosmin, Myocardial SPECT, Ischemic heart disease, Percent uptake increase, Coronary flow reserve.

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