| Japanese |
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| Title | 123I - Iomazenilの早期および後期脳SPECT像とコンパートメント解析との比較 |
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| Subtitle | 原著 |
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| Authors | 柳元真一*, 小野志磨人*, 曽根照喜*, 森田浩一*, 永井清久*, 大塚信昭*, 三村浩朗*, 友光達志*, 福永仁夫*, 村中明*, 板谷道信**, 北山彰** |
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| Authors(kana) | |
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| Organization | *川崎医科大学核医学科, **川崎医療短大放射線技術科 |
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| Journal | 核医学 |
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| Volume | 34 |
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| Number | 6 |
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| Page | 371-377 |
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| Year/Month | 1997/6 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」成人12例(男女各6例, 平均56.1歳)を対象に, 123I-Iomazenil(IMZ)による脳SPECT像の特徴を検討した. 投与15分後と3時間後のSPECT像から, 123I-IMZの脳内よりの洗い出し率を評価した. 洗い出しは比較的緩徐であったが, 脳内の各領域で洗い出し率は異なり, 123I-IMZの脳内分布は経時的に変化していくことが示唆された. さらに, 123I-IMZの脳内動態を3コンパートメント, 2パラメータモデルと仮定して, 血中から脳組織への移行定数(K1)とベンゾジアゼピン受容体への結合能指標(BP)を算出した. BPとK1は, 123I-IMZのSPECTカウントおよび123I-IMPによる脳血流値と比較検討した. BP値は, 123I-IMZ投与早期よりも, 後期SPECTカウントと良好に相関し, 後期SPECT像の方がベンゾジアゼピン受容体の分布をより反映していることが確認された. 他方, K1値は123I-IMPにより得られた脳血流値と高度の相関を示したことから, 投与後超早期のSPECT像は局所脳血流分布の影響を大きく反映している可能性が高いと考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | 123I-Iomazenil, Benzodiazepine receptor, SPECT. |
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| English |
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| Title | Compartment Analysis of 123I - Iomazenil Brain on Early and Delayed SPECT |
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| Subtitle | Original Articles |
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| Authors | Shinichi YANAGIMOTO*, Shimato ONO*, Teruki SONE*, Koichi MORITA*, Kiyohisa NAGAI*, Nobuaki OTSUKA*, Hiroaki MIMURA*, Tatsushi TOMOMITSU*, Masao FUKUNAGA*, Akira MURANAKA**, Michinobu ITAYA**, Akira KITAYAMA** |
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| Authors(kana) | |
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| Organization | *Department of Nuclear Medicine, Kawasaki Medical School, **Department of Radiologycal Technology, Kawasaki College of Allied Health Professions |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 34 |
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| Number | 6 |
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| Page | 371-377 |
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| Year/Month | 1997/6 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]We investigated the characteristics of 123I-Iomazenil(IMZ)SPECT images in 12adults(six males and six females, with a mean age of 56.1 years). The washout rate of 123I-IMZ from the brain was estimated from two SPBCTs done 15min and 3 hr after injection. Although the washout was relatively slow, the rates differed in each intracerebral region, suggesting that the distribution of 123I-IMZ was gradually changing. Furthermore, assuming 123I-IMZ kinetics in the brain for the three-compartment, two-parameter model, the transition rate constant(K1)from the blood to the brain and the binding potentials(BP)of benzodiazepine to the receptor were calculated. The BP and K1 values were compared with 123I-IMZ SPECT counts and CBF values by 123I-IMP. The BP values correlated more closely with the counts on the delayed SPECT than those on the early SPECT. It was confirmed that delayed SPECT images reflect better the distribution of the benzodiazepine receptor than early images do. On the other hand, the K1 values correlated highly with CBF obtained by 123I-IMP, and this finding suggested that super-early SPECT images might be remarkably influenced by the distribution of CBF. |
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| Practice | Clinical medicine |
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| Keywords | 123I-Iomazenil, Benzodiazepine receptor, SPECT. |
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