| Japanese |
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| Title | 1コンパートメントモデルに基づく99mTc-MAG3血漿クリアランス算出法 (MPC法) の小児への応用 |
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| Subtitle | 《技術報告》 |
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| Authors | 小泉潔*, 東田耕輔**, アリ S アルバブ***, 遠山敬司***, 新井誉夫****, 吉富達也**** |
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| Authors(kana) | |
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| Organization | *東京医科大学八王子医療センター放射線科, **山梨医科大学小児科, ***山梨医科大学放射線科, ****山梨医科大学附属病院放射線部 |
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| Journal | 核医学 |
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| Volume | 34 |
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| Number | 4 |
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| Page | 259-265 |
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| Year/Month | 1997/4 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」1コンパートメントモデルに基づき99mTc-MAG3血漿クリアランスを算出するMPC法を小児に応用し, その算出結果に影響を及ぼす腎の深さ測定法と分布容積(循環血漿量)推定法に検討を加えた. 小児腎の深さの推定は伊藤(和夫)により報告された式が適していると考えられた. ヘマトクリットが正常から大きく隔たっていないと想定されれば, 循環血漿量は体重の5%と推定してもよいと考えられた. 以上の2点を取り入れたMPC簡便法はRussellの1点採血法による値と有意な正相関を示し, したがって, MPC法による99mTc-MAG3血漿クリアランス測定法は小児においても適用可能な方法と結論できた. 「I. はじめに」99mTc-mercaptoacetyltriglycine(99mTc-MAG3)は腎シンチグラフィ用放射性医薬品であり, 1回の腎循環により高い除去率で近位尿細管より分泌される. |
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| Practice | 臨床医学：一般 |
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| Keywords | 99mTc-MAG3, Plasma clearance, Renal function, Radionuclide renal study. |
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| English |
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| Title | Application of Measuring 99mTc-MAG3 Plasma Clearance Based on One-Compartment Model (MPC Method) to Pediatric Patients |
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| Subtitle | |
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| Authors | Kiyoshi KOIZUMI*, Kousuke HIGASHIDA**, Ali S.ARBAB***, Keiji TOYAMA***, Takao ARAI****, Tatsuya YOSHITOMI**** |
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| Authors(kana) | |
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| Organization | *Department of Radiology, Tokyo Medical College, Hachioji Medical Center, **Department of Pediatrics, Yamanashi Medical University, ***Department of Radiology, Yamanashi Medical University, ****Department of Radiology, Yamanashi Medical University Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 34 |
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| Number | 4 |
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| Page | 259-265 |
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| Year/Month | 1997/4 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | Measurement of 99mTc-MAG3 plasma clearance based on 1-compartment model (MPC method) were applied to 12 pediatric patients and evaluated for the factors which might affect the calculated results. Depth correction is a critical factor for the measurement of renal uptake. Three different equations for estimating renal depth were compared with the real depth measured by ultrasonography. The equation proposed by K. Itoh was suitable though the equations by T. Ito and Raynaud were insufficient. Estimation of distribution volume, which is regarded as circulating plasma volume (CPV), is also critical for the calculation of MAG3 clearance by MPC method. Precisely, hematocrit measured by venous sampling and circulating blood volume (CBV) calculated as 7.5% of body weight are used for estimation of CPV. However, assumed CPV as 5% of body weight was acceptable if the hematocrit was not severely deviated from the normal value. Simplified MPC method utilizing two factors mentioned above gave a positive correlation with Russell's one point sampling method. In conclusion, MPC method is applicable for pediatric patients. |
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| Practice | Clinical medicine |
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| Keywords | 99mTc-MAG3, Plasma clearance, Renal function, Radionuclide renal study. |
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