| Japanese |
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| Title | 99mTc-Tetrofosminを用いた急性心筋梗塞症における経皮的冠動脈形成術前後の血流評価 |
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| Subtitle | 《原著》 |
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| Authors | 河合裕子*, 塚本江利子**, 山口隆義*, 赤城秀哉*, 木住野皓*, 甲谷哲郎***, 玉木長良** |
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| Authors(kana) | |
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| Organization | *北光循環器病院, **北海道大学医学部核医学講座, ***北海道大学医学部循環器内科 |
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| Journal | 核医学 |
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| Volume | 34 |
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| Number | 4 |
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| Page | 221-228 |
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| Year/Month | 1997/4 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」急性心筋梗塞症に対する再灌流療法前後の心筋血流分布を99mTc-Tetrofosmin(TF)SPECTを用いて撮像し, 心筋salvage効果を経時的に評価した. 対象は急性心筋梗塞28例で, 発症から6時間以内のPTCA施行17例(早期群), 6時間を超えて施行11例(晩期群)の2群にわけた. SPECT撮像はPTCA施行直後, 1週間後, 4週間後に行い, 各々を急性期, 亜急性期, 慢性期像とした. SPECT像の集積程度を4段階に分けてtotal defect scoreを算出した. 早期群のdefect scoreは急性期に13±7, 亜急性期6±5, 慢性期3±4と著明に減少した. 晩期群では18±7, 14±7, 13±7と有意に減少したが, その程度は小さかった. 急性期から亜急性期までの改善度は早期群で60±23%, 晩期群では20±17%であり, 早期群の方が有意に大きかった. 以上より, Tetrofosminの特性を生かしたfreezing imageを用いることによって急性心筋梗塞症における再灌流療法前後の経時的な心筋salvage効果の程度が評価でき, 心筋梗塞発症からPTCA施行までの時間の違いによりその後の改善経過が異なるという治療効果を視覚的に判定することができた. |
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| Practice | 臨床医学：一般 |
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| Keywords | 99mTc-tetrofosmin, Acute myocardial infarction, Direct PTCA, Defect score. |
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| English |
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| Title | Evaluation of Myocardial Perfusion by 99mTc-Tetrofosmin SPECT before and after Emergent Percutaneous Transluminal Coronary Angioplasty for Acute Myocardial Infarction |
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| Subtitle | - Original Articles - |
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| Authors | Yuko KAWAI*, Eriko TSUKAMOTO**, Takayoshi YAMAGUCHI*, Hideya AKAGI*, Koh KISHINO*, Tetsuro KOHYA***, Nagara TAMAKI** |
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| Authors(kana) | |
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| Organization | *Hokko Cardiovascular Hospital, **Department of Nuclear Medicine, Hokkaido University School of Medicine, ***Department of Cardiology, Hokkaido University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 34 |
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| Number | 4 |
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| Page | 221-228 |
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| Year/Month | 1997/4 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | To assess clinical performance of coronary perfusion in patients with acute myocardial infarction following successful PTCA, various 99mTc-tetrofosmin (TF) SPECT were obtained. Twenty-eight patients with acute myocardial infarction underwent TF SPECT before emergent PTCA (acute phase), after 7 days (subacute phase) and 4 weeks (chronic phase) later. Twenty-eight patients divided into 2 groups. Early group; time lug from onset of AMI till PTCA is 6 hours or shorter (n=17), delayed group; time lug is more than 6 hrs (n=11). The defect scores were graded by 4 points grading system (0 as normal to 3 as defect) in 14 myocardial segments. In early group, the mean defect score was 13+-7 at acute phase, 6+-5 at subacute phase, and 3+-4 at chronic phase. In delayed group, the mean value of defect score at each phases were 18+-7, 14+-7, and 13+-7. The improvement of defect score of early group was significantly larger than that of delayed group (p<0.005). These data indicate that PTCA therapy for acute MI patients is useful particularly in the early stage following acute MI. |
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| Practice | Clinical medicine |
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| Keywords | 99mTc-tetrofosmin, Acute myocardial infarction, Direct PTCA, Defect score. |
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