| Japanese |
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| Title | 123I-IMP, 99mTc-HMPAOおよび99mTc-ECDによる脳血流SPECT画像の比較検討 |
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| Subtitle | 《短報》 |
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| Authors | 小田野行男*, 大久保真樹**, 高橋誠*, 野口栄吉*, 大滝広雄*, 笠原敏文*, 柴木充朗*, 羽田野政義* |
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| Authors(kana) | |
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| Organization | *新潟大学医学部放射線科, **新潟大学医療技術短期大学部診療放射線技術学科 |
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| Journal | 核医学 |
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| Volume | 34 |
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| Number | 3 |
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| Page | 189-194 |
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| Year/Month | 1997/3 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」123I-IMP, 99mTc-HMPAOおよび99mTc-ECDのSPECT画像の特性を比較検討するため, 変性疾患や脳梗塞など7例を対象に, 同一の時期に同一の装置で3種のトレーサによるSPECT検査を施行した. HMPAOに関しては, Lassen補正を行った場合(補正(+))と行わなかった場合(補正(-))も検討した. 集積パターンと画像コントラストを定量的に評価するため, 領域/大脳比(Uptake ratio)とその変動係数を定義して測定し比較した. Uptake ratioの変動係数は, HMPAO補正(+)>IMP>ECD>HMPAO補正(-)の順で低くなり, 画像のコントラストはHMPAO補正(+)が最もよく, HMPAO補正(-)が最も不良であった. HMPAOは脳血流を定量化するしないにかかわらず, 画像コントラストを改善するためにLassen補正を行うべきと考えられた. Uptake ratioは, 脳幹, 視床, 後頭葉および白質で有意差が見られた. ECDのUptake ratioはIMPに比較して脳幹, 視床で有意な低値となり, HMPAO(補正(+))のそれは脳幹で有意に低値であった. IMPに比較して, ECDおよびHMPAO(補正(-))のUptake ratioは後頭葉で有意な高値を示した. ECDの脳幹と視床における低集積は, エステラーゼ活性の低下や脳血管透過性の減少などが原因と推測される. 脊髄小脳変性症など脳幹病変の有無が問題となる場合には, ECDおよびHMPAOには問題があり, IMPを使用するのがよいと思われた. |
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| Practice | 臨床医学：一般 |
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| Keywords | 123I-IMP, 99mTc-HMPAO, 99mTc-ECD, SPECT. |
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| English |
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| Title | A Comparative Study of the Quality of SPECT Images Obtained by 123I-IMP, 99mTc-HMPAO and 99mTc-ECD |
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| Subtitle | - Short Communication - |
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| Authors | Ikuo ODANO*, Masaki OHKUBO**, Makoto TAKAHASHI*, Eikichi NOGUCHI*, Hiro OHTAKI*, Toshifumi KASAHARA*, Mitsurou SHIBAKI*, Masayoshi HATANO* |
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| Authors(kana) | |
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| Organization | *Department of Radiology, Niigata University School of Medicine, **Department of Radiological Technology, College of Biomedical Technology, Niigata University |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 34 |
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| Number | 3 |
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| Page | 189-194 |
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| Year/Month | 1997/3 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | The purpose of this study was to comparatively evaluate the quality of SPECT images for the mapping of rCBF using three tracers, 123I-IMP, 99mTc-HMPAO and 99mTc-ECD. We performed three SPECT studies on seven patients with various cerebral diseases under the same conditions. An effect of Lassen's correction on SPECT images obtained by HMPAO was also evaluated. The same irregular regions of interest were placed on the four transaxial SPECT images. To quantitatively evaluate the pattern of tracer uptake and image contrast, the uptake ratio, regional count/mean count of the cerebrum, and its coefficient variations (CV) were defined, respectively. The order of the value of CV was HMPAO with correction>IMP>ECD>HMPAO without correction. HMPAO with correction showed the best image contrast, but HMPAO without correction was the worst. Uptake ratios of ECD and HMPAO with correction were decreased in the brain stem and thalamus in comparison with those of IMP. Both uptake ratios of ECD and HMPAO without correction were increased in the occipital cortex. IMP provides high quality SPECT images. Images obtained by HMPAO should be modified by Lassen's correction to increase image contrast. ECD or HMPAO should not be used to evaluate patients with spinocerebellar degeneration. |
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| Practice | Clinical medicine |
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| Keywords | 123I-IMP, 99mTc-HMPAO, 99mTc-ECD, SPECT. |
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