| Japanese |
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| Title | 慢性閉塞性肺疾患における肺血流分布半定量と肺機能 |
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| Subtitle | 《原著》 |
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| Authors | 内田耕*, 中山浩之*, 山上育恵*, 高橋秀樹**, 高野政明** |
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| Organization | *東邦大学医学部第二内科, **東邦大学大森病院中央放射線RI診断部 |
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| Journal | 核医学 |
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| Volume | 34 |
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| Number | 3 |
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| Page | 145-149 |
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| Year/Month | 1997/3 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」慢性閉塞性肺疾患患者56名, 健常成人男子19名に換気血流シンチグラムおよび肺機能検査を施行した. 133Xe肺容量像は再呼吸相のカウントを加算して作製し, その関心領域は, 肺輪郭を表すように設定して求め, 領域内の画素数をLとした. 99mTc-MAA血流像の関心領域はカットオフレベルを50%, 70%, 90%に設定して求め, 領域内の画素数を各々P50, P70, P90とし, PおよびP/Lと肺機能との関係を調べた. P/LはPに比して, 肺機能との相関が高かった. カットオフレベル50%, 70%, 90%で比較すると, P70およびP70/Lは最も多くの肺機能指標と有意な相関があった. P70およびP70/Lは低酸素血症を有する患者で有意に低下し, COPDの重症度の判定にも有用と考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | 99mTc-macroaggregated albumin, 133Xe gas, Semiquantitative analysis, Chronic obstructive pulmonary disease, Pulmonary function. |
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| English |
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| Title | Correlation of Semiquantitative Analysis of the Distribution of Pulmonary Perfusion with Pulmonary Function in Chronic Obstructive Pulmonary Disease |
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| Subtitle | - Original Articles - |
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| Authors | Kou UCHIDA*, Hiroyuki NAKAYAMA*, IKue YAMAGAMI*, Hideki TAKAHASHI**, Masaaki TAKANO** |
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| Authors(kana) | |
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| Organization | *Second Department of Internal Medicine, Toho University School of Medicine, **Department of Radiology, Toho University Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 34 |
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| Number | 3 |
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| Page | 145-149 |
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| Year/Month | 1997/3 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | We carried out ventilation-perfusion scintigraphy and pulmonary function tests in 56 patients with chronic obstructive pulmonary disease (COPD) and 19 healthy volunteers. We used 99mTc-macroaggregated albumin for the perfusion scintigraphy and 133Xe gas for the ventilation scintigraphy. The lung volume image was created by computerized summation of the radioactivity in the rebreathing phase. Regions of interest (ROIs) were set automatically on lung volume image, which included each whole lung, and on perfusion image, including areas with relatively high radioactivity, with cut-off levels of 50%, 70%, and 90%. The number of pixels in each ROI was used as an index of lung volume (L) or perfusion (P). Perfusion per unit of lung volume (P/L) was also used as an index of perfusion. P70 and P70/L showed the better correlations than the other parameters, including significant correlations with vital capacity, FEV1.0, peak flow rate, RV/TLC, diffusing capacity and arterial oxygen partial pressure. The significant difference in P70 and P70/L between patients with hypoxemia and those without hypoxemia suggested that P70 and P70/L are useful indicators of the severity of COPD. We conclude that semiquantified values of pulmonary perfusion scintigraphy are significantly correlated with pulmonary function and the severity of COPD. |
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| Practice | Clinical medicine |
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| Keywords | 99mTc-macroaggregated albumin, 133Xe gas, Semiquantitative analysis, Chronic obstructive pulmonary disease, Pulmonary function. |
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