| Japanese |
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| Title | 骨軟部病変の99mTc-MIBIによる評価 : 201Tlとの比較ならびに化学療法の治療効果との関連について |
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| Subtitle | 《原著》 |
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| Authors | 隅屋寿*, 滝淳一*, 利波紀久*, 朝田尚宏**, 土屋弘行**, 富田勝郎** |
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| Organization | *金沢大学医学部核医学科, **金沢大学医学部整形外科 |
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| Journal | 核医学 |
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| Volume | 34 |
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| Number | 2 |
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| Page | 105-111 |
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| Year/Month | 1997/2 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」骨軟部病変を有する患者35例を対象に99mTc-MIBIおよび201Tlシンチグラフィを施行し, 静注15分後の早期像と3時間後の後期像とを平面像で比較した. 視覚的評価とともに定量的評価として, 病変とバックグラウンドの平均カウント比(uptake ratio)を算出した. 早期像では99mTc-MIBIの病変部の集積の強さは201Tlとほぼ同等であり, 骨軟部病変に対して有用なトレーサと考えられた. 後期像においては99mTc-MIBIより201Tlの方が病変部の集積がやや強い傾向がみられたが, 有意差はなかった. しかしながら, 99mTc-MIBIは後期像でのwashoutが強い症例があり, 集積の有無の評価に早期像は不可欠であった. 後期像のuptake ratioが1.20以下の症例は, いずれも化学療法が無効であり, 悪性腫瘍における99mTc-MIBIの後期像での集積低下が化学療法の効果予測に応用できる可能性が示された. |
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| Practice | 臨床医学：一般 |
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| Keywords | Thallium, MIBI, Bone and soft tissue tumor, Chemotherapy, Multidrug resistance. |
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| English |
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| Title | Evaluation of Bone and Soft Tissue Lesion Using 99mTc-MIBI : Comparison with 201Tl and the Relation to Chemotherapeutic Effect |
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| Subtitle | - Original Articles - |
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| Authors | Hisashi SUMIYA*, Junichi TAKI*, Norihisa TONAMI*, Naohiro ASADA**, Hiroyuki TSUCHIYA**, Katsuro TOMITA** |
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| Authors(kana) | |
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| Organization | *Department of Nuclear Medicine, **Department of Orthopedics, School of Medicine, Kanazawa University |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 34 |
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| Number | 2 |
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| Page | 105-111 |
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| Year/Month | 1997/2 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | Thirty-five patients with bone and soft tissue lesions were studied with 99mTc-MIBI and 201Tl to compare the uptake of two tracers. Planar images were obtained 15 min (early image) and 3 hr (delayed image) after the injection of both tracers. Images were evaluated visually and quantitatively using uptake ratio (lesion/background). In visual analysis, 23 of 35 patients showed similar uptake of both tracers, 9 showed more intense uptake of 99mTc-MIBI than 201Tl, and 3 showed more intense uptake of 201Tl than 99mTc-MIBI on early images. On delayed images, 21 of 32 patients showed similar uptake of both tracers, 3 showed more intense uptake of 99mTc-MIBI than 201Tl, and 8 showed more intense uptake of 201Tl than 99mTc-MIBI. In quantitative analysis, similar 201Tl and 99mTc-MIBI uptake ratios were obtained on early images. On delayed images, 99mTc-MIBI uptake ratios are less than that of 201Tl, but the difference was not significant. In some cases, 99mTc-MIBI accumulation was washed out on delayed images, therefore the early image is essential to evaluate 99mTc-MIBI accumulation. In all cases with the uptake ratios less than 1.20 on delayed 99mTc-MIBI images, chemotherapy was not effective. In malignant tumors, decreased uptake of 99mTc-MIBI accumulation on delayed images may indicate that chemotherapy is not effective. Delayed 99mTc-MIBI image may be a potential marker predicting chemotherapeutic effect in malignant bone and soft tissue tumors. |
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| Practice | Clinical medicine |
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| Keywords | Thallium, MIBI, Bone and soft tissue tumor, Chemotherapy, Multidrug resistance. |
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