| Japanese |
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| Title | 運動負荷 / 安静99mTc-tetrofosmin心筋SPECTを用いた冠血流予備能指標の算出 |
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| Subtitle | 《短報》 |
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| Authors | 木下法之*, 杉原洋樹**, 中村智樹*, 伊藤一貴*, 東秋弘*, 前田知穂**, 中川雅夫* |
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| Organization | *京都府立医科大学第二内科, **京都府立医科大学放射線科 |
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| Journal | 核医学 |
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| Volume | 34 |
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| Number | 1 |
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| Page | 45-48 |
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| Year/Month | 1997/1 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」安静時に対する運動負荷時の99mTc-tetrofosmin(TF)心筋摂取の変化率を1日法にて算出する方法を考案し, 冠血流予備能指標としての可能性を検討した. 正常15例を対象として, 最大運動負荷時にTF 370 MBqを静注し, 30分後(TF1), 3時間後(TF2)に撮像した. TF2撮像後TF 740 MBqを静注し, 30分後に撮像(TF3)した. TF1, TF2, TF3の心筋カウントを各々C1, C2, C3とし, 運動負荷時の安静時に対するTF心筋摂取の変化率(ΔMTU: A myocardial tetrofosmin uptake)を次式より算出した. ΔMTU=[{Cl/(C3-C2)}×R-1]×100(%)(R: 投与量比)正常15例の心全体のΔMTUは57.8±9.9%であった. ΔMTUと運動時の最大心拍数およびdouble productは粗な正相関を示した. 安静時と運動負荷時でTFのextraction fractionが変化しないと仮定すると, ΔMTUは安静時に対する運動負荷時の冠血流量/心拍出量の変化率に相当すると考えられる. ΔMTUは, 冠血流予備能に相当する指標となり得ることが示唆された. |
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| Practice | 臨床医学：一般 |
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| Keywords | 99mTc-tetrofosmin, Myocardial SPECT, Coronary flow reserve. |
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| English |
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| Title | A Calculation of an Index of the Coronary Flow Reserve Using Exercise and Rest Myocardial SPECT with 99mTc-Tetrofosmin |
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| Subtitle | - Short Communication - |
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| Authors | Noriyuki KINOSHITA*, Hiroki SUGIHARA**, Tomoki NAKAMURA*, Kazuki ITO*, Akihiro AZUMA*, Tomoho MAEDA**, Masao NAKAGAWA* |
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| Authors(kana) | |
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| Organization | *Second Department of Medicine, Kyoto Prefectural University of Medicine, **Department of Radiology, Kyoto Prefectural University of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 34 |
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| Number | 1 |
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| Page | 45-48 |
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| Year/Month | 1997/1 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | We designed a new method to evaluate the rate of change of myocardial 99mTc-tetrofosmin (TF) uptake between exercise and rest images with a 1-day protocol. Fifteen normal cases were studied. A 370 MBq of TF was injected at peak exercise. Initial (TF1) and delayed (TF2) exercise SPECT images were acquired 30 min and 3 hr after the injection. A 740 MBq of TF was reinjected soon after TF2 acquisition, and rest SPECT images (TF3) were obtained 30 min after the reinjection. Myocardial counts of TF1, TF2 and TF3 were defined C1, C2 and C3 respectively. Then, the rate of change of myocardial TF uptake between exercise and rest (ΔMTU: Δ myocardial TF uptake) was determined by the following formula. ΔMTU=[{1/(C3-C2)}×R-1]×100 (%) (R: dose ratio). ΔMTU was 57.8+-9.9% in normal cases and roughly correlated with maximal heart rates and double product. If the extraction fraction of TF is not changed under the exercise and resting condition, ΔMTU may have some relation with the coronary flow/cardiac output ratio at exercise. In conclusion, ΔMTU is a useful index to evaluate coronary flow reserve non-invasively. |
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| Practice | Clinical medicine |
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| Keywords | 99mTc-tetrofosmin, Myocardial SPECT, Coronary flow reserve. |
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