| Japanese |
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| Title | 分割投与99mTc-ECD SPECTによるDiamox負荷前後の局所脳血流測定と補正法の開発 |
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| Subtitle | 《原著》 |
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| Authors | 曽我部一郎* |
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| Organization | *愛媛大学医学部放射線医学教室 |
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| Journal | 核医学 |
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| Volume | 34 |
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| Number | 1 |
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| Page | 35-44 |
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| Year/Month | 1997/1 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」99mTC-ECDと持続動脈採血により, Diamox負荷前後の局所脳血流量(rCBF)を連続して測定する方法を考案し, 加えて, 高血流域における一回循環摂取率の低下に起因する過小評価の補正法を開発した. 5名の被検者において, microsphereモデルにより算出されたrCBFは, 133Xe吸入法によるrCBF(133Xe-CBF)に対し高血流域において過小評価され, 回帰直線の傾きは0.576であった. この検査方法の再現性を, 別の5名の被検者において検討したところ, rCBFに関して良好な結果を得た. 133Xe-CBFとの直線化補正を行うため, permeability surface area productモデルに基づく補正法を考案した. 14名の脳血管障害患者に応用し, 補正前後における131Xe-CBFとの相関係数は0.697と0.699で変わらなかったが, 回帰直線の傾きは0.427から0.865に改善した. 本法はDiamox負荷後の高血流域においても133Xe-CBFと同等の値が得られ, 脳循環予備能を正確に評価できる点で臨床的に有用と考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | SPECT, 99tmTc-ECD, Diamox, Linearization correction, rCBF. |
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| English |
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| Title | Regional Cerebral Blood Flow Measurements at Pre- and Post-Diamox Test Using Split Dose 99mTc-ECD SPECT : Comparison with 133Xe Inhalation Method and Linearization Correction |
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| Subtitle | - Original Articles - |
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| Authors | Ichiro SOGABE |
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| Authors(kana) | |
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| Organization | Department of Radiology, Ehime University School Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 34 |
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| Number | 1 |
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| Page | 35-44 |
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| Year/Month | 1997/1 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | A new method for quantitative measurement of regional cerebral blood flow (rCBF) before and after acetazolamide (Diamox(R)) administration was developed using 99mTc labeled ethyl cysteinate dimer (ECD) and consecutive SPECT with continuous arterial blood sampling. Moreover, the correction was proposed for underestimation of rCBF due to the inherent low first pass extraction of ECD in high blood flow regions. The rCBF values obtained by the microsphere model in s patients correlated well with those obtained by 133Xe gas inhalation method. The slope of the regression line, however, was 0.576 due to the underestimation of high CBF values. The reproducibility of two resting rCBF obtained by the microsphere model proposed here was confirmed in another 5 patients with the mean values of 41.8+-5.6 ml/100 g/min and 38.9+-5.3 ml/100 g/min for the 1st and 2nd measurement, respectively. The correction of rCBF obtained with BCD and the proposed microsphere model was performed using the permeability-surface area product model described by Crone. In 14 patients with cerebrovascular diseases, the corrected rCBFs correlated well with those by 133Xe gas inhalation method with the improvement of the slope of regression line (0.427 to 0.865), although the correlation coefficient did not change significantly (0.697 to 0.699). The results indicated that the proposed correction method could reflect precisely the increase in rCBF elicited after Diamox administration, so that the cerebral perfusion reserve could be evaluated more exactly than the methods which have ever been utilized in the routine clinical measurements. |
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| Practice | Clinical medicine |
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| Keywords | SPECT, 99tmTc-ECD, Diamox, Linearization correction, rCBF. |
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