Japanese
Title肥大型心筋症における123I-BMIPP所見の経年的変化の検討
Subtitle原著
Authors奥山智緒*, 杉原洋樹*, 伊藤一貴**, 米山聡嗣**, 寺田幸治**, 谷口洋子**, 松本雄賀**, 牛嶋陽*, 中川雅夫**, 前田知穂*
Authors(kana)
Organization*京都府立医科大学放射線科, **京都府立医科大学第二内科
Journal核医学
Volume33
Number12
Page1329-1336
Year/Month1996/12
Article原著
Publisher日本核医学会
Abstract「要旨」 肥大型心筋症(HCM)における123I-BMIPP心筋SPECT所見の経年的変化を検討した. HCM16症例を対象とし, 123I-BMIPPシンチグラフィを施行した. 再構成したSPECT画像の左室を17領域に分割して, 各領域の集積低下度を4段階評価し, 平均25±14か月後に再検し, 経年的変化を検討した. 初回施行時の123I-BMIPP心筋SPECTでは, 14例(88%)に集積低下が認められ, 集積低下は前壁中隔接合部と後壁中隔接合部に多く認められた. 再検時には, 初回と比較し, 123I-BMIPP心筋SPECT所見は, 16例中7例(44%)が悪化, 1例(6%)が改善, 8例(50%)が不変であった. 悪化群の中でTlシンチ所見や心機能の悪化を認めたものは拡張相の1例のみであった. HCMには心筋脂肪酸代謝障害が比較的短期間に進行する症例が存在し, 123I-BMIPP心筋SPECTはHCMの病期や病変の進行度の推定に寄与する可能性が示唆された.
Practice臨床医学：一般
KeywordsHypertrophic cardiomyopathy, 123I-BMIPP, Myocardial fatty acid metabolism, Serial change
English
TitleThe Serial Change of the 123I-BMIPP SPECT in Patients with Hypertrophic Cardiomyopathy
SubtitleOriginal Articles
AuthorsChio OKUYAMA*, Hiroki SUGIHARA*, Kazuki ITO**, Satoshi YONEYAMA**, Kouji TERADA*, Yoko TANIGUCHI**, Katsushige MATSUMOTO**, Yo USHIJIMA*, Masao NAKAGAWA**, Tomoho MAEDA*
Authors(kana)
Organization*Department of Radiology, Kyoto Prefectural University of Medicine, **Second Department of Medicine, Kyoto Prefectural University of Medicine
JournalThe Japanese Journal of nuclear medicine
Volume33
Number12
Page1329-1336
Year/Month1996/12
ArticleOriginal article
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
Abstract[Summary] We studied the serial change of 123I-BMIPP SPECT in the process of hypertrophic cardiomyopathy (HCM). In 16 patients with HCM, the imaging data were acquired 15 minutes after injection of 111 MBq 123I-BMIPP. The SPECT image was divided into 17 segments and the severity of the defect in each segment was scored visually using defect score, a 4-point grading system (score 0 = normal, score 1=mildly decreased uptake, score 2 = moderately decreased uptake, score 3 = severely decreased uptake or defect). Each patient underwent this examination twice with interval of 25+-14 months. In the first examination, we observed reduced uptake in 14 cases (88%), and often found it in septal portion of anterior or posterior wall. In the second examination, compared with the first study, total defect score (TDS: the summation of defect score of 17 segments) had increased in 7 cases (44%) of 16 cases, decreased in only 1 case (6%), and unchanged in 8 cases (50%). The regional defect score often increased in septal portion of anterior and posterior walls, and the high score area widespread toward the septum. There was no difference between TDS unchanged group and TDS worsened group in the point of back-ground (age, family history of HCM), the interval of the two studies, and the findings of echocardiography (Dd, Ds, %F). In TDS worsened group (n=7), clinically only 1 case became progressed stage. In others there were no progression in each clinical, echocardiographic, or 201Tl scintigraphic findings. This study revealed that myocardial fatty acid metabolic disorder often progresses during short interval in patients with HCM. In conclusion, the serial examination of 123I-BMIPP SPECT may contribute to an estimation of the stage or the prognosis in HCM.
PracticeClinical medicine
KeywordsHypertrophic cardiomyopathy, 123I-BMIPP, Myocardial fatty acid metabolism, Serial change

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