| Japanese |
|---|
| Title | 99mTc-MAG3を用いたdynamic SPECTによる移植腎内血流動態の評価 - グラフプロット解析による検討 - |
|---|
| Subtitle | 《原著》 |
|---|
| Authors | 赤平秀昭* |
|---|
| Authors(kana) | |
|---|
| Organization | *鷹揚郷腎研究所弘前病院放射線科 |
|---|
| Journal | 核医学 |
|---|
| Volume | 33 |
|---|
| Number | 11 |
|---|
| Page | 1227-1237 |
|---|
| Year/Month | 1996/11 |
|---|
| Article | 原著 |
|---|
| Publisher | 日本核医学会 |
|---|
| Abstract | 「要旨」99mTc-MAG3による腎dynamic SPECTに, 4-コンパートメントモデルとグラフプロット解析を応用し, 移植腎患者23例を対象に腎血流量および尿細管機能の評価を試みた. 血清クレアチニン値(SCr)別にI群7例, II群11例およびIII群5例とし, 尿細管細胞への移行定数K3を腎機能別にみると, SCrレベルからはI>II>III群の順に有意な差を示し, 尿素窒素(BUN)およびクレアチニンクリアランス(Ccr)とも良好に相関した. 腎内移行定数K1はI群とII群間に有意差はなく, III群のみで低下し, SCr, BUNおよびCcrと相関したが, 相関係数は0.7前後でK3よりも小さく, K1およびK3は必ずしも平行しないことが判った. 腎内分布定数Vd12ではK3と類似の傾向がみられた. K1およびK3を用いて算出した有効腎血漿流量(ERPF)は, Bubeck法のtubular extraction rate(TER)と良好な相関を認めた. これらの成績ならびに, 病理組織所見等との対比から, K1, K3およびVd12は, それぞれ腎内の中枢側, 末梢側の血流動態および99mTc-MAG3の尿細管摂取機能を評価する上で有用な指標と考えられた. |
|---|
| Practice | 臨床医学：一般 |
|---|
| Keywords | 99mTc-mercaptoacetyltriglycine (99mTc-MAG3), Dynamic SPECT, Compartment model, Graphic analysis, Renal allograft dysfunction. |
|---|
| English |
|---|
| Title | Evaluation of Renal Allograft Dysfunction Employing Dynamic SPECT with 99mTc-MAG3 and Graph Plot Analysis |
|---|
| Subtitle | - Original Articles - |
|---|
| Authors | Hideaki AKAHIRA |
|---|
| Authors(kana) | |
|---|
| Organization | Department of Radiology, Oyokyo Kidney Research Institute, Hirosaki Hospital |
|---|
| Journal | The Japanese Journal of nuclear medicine |
|---|
| Volume | 33 |
|---|
| Number | 11 |
|---|
| Page | 1227-1237 |
|---|
| Year/Month | 1996/11 |
|---|
| Article | Original article |
|---|
| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
|---|
| Abstract | To estimate renal blood flow and tubular function in transplanted kidneys, we applied the 4 compartments model and the graphic analysis method to 99mTc-MAG3 dynamic SPECT and calculated some parameters, i.e. K1 (renal influx rate constant), K3 (tubular transporting rate constant), Vd12 (intrarenal distribution volume), and others. Twenty-three renal transplant recipients were examined and divided into following 3 groups according to their serum creatinine levels (SCr); Group I: less than 1.3 mg/dl (1.1+-0.3, n=7), Group II: 1.4-2.5 mg/dl (1.8+-0.3, n=11), and Group III more than 2.6 mg/dl (3.9+-0.9, n=5). The K3 value became lower in the order of Group I>II>III, and well correlated with blood urea nitrogen (BUN, r=-0.95, p<0.001) and creatinine clearance (Ccr, r=0.78, p<0.001). The K1 value reduced markedly in Group III despite of no difference between Group I and II. Although the K1 value also correlated with SCr, BUN and Ccr, correlation coefficients were smaller than those with the K3. Effective renal plasma flow derived from K1 and K3 showed a good correlation with the tubular extraction rate by Bubeck's method. From these results and clinical conditions including histopathological findings, it is suggested that K1, K3 and Vd12 are useful parameters of renal central arterial blood flow, renal peripheral arteriolar blood flow and renal 99mTc-MAG3 uptake function, respectively. |
|---|
| Practice | Clinical medicine |
|---|
| Keywords | 99mTc-mercaptoacetyltriglycine (99mTc-MAG3), Dynamic SPECT, Compartment model, Graphic analysis, Renal allograft dysfunction. |
|---|