| Japanese |
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| Title | 化学療法剤シスプラチン投与後の骨シンチグラフィ腎異常集積に影響を与える因子の解析 |
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| Subtitle | 《原著》 |
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| Authors | 佐藤多智雄*, 吉岡清郎*, 尾形優子**, 阿部由直*, 高橋寿太郎*, 山田健嗣**, 小野修一*, 福田寛* |
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| Authors(kana) | |
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| Organization | *東北大学加齢医学研究所機能画像医学研究分野, **仙台厚生病院放射線科 |
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| Journal | 核医学 |
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| Volume | 33 |
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| Number | 11 |
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| Page | 1221-1226 |
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| Year/Month | 1996/11 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」化学療法剤CDDP投与後に骨シンチグラム上で99mTc-MDPが両腎実質へ集積して異常像が認められる. 骨シンチグラムのフイルム上で腎濃度と骨濃度の比を腎集積指数として, 腎異常集積を評価した. CDDPを中心とする化学療法が施行されて30日以内に骨シンチグラフィが行われた21例を対象とした. これらの症例のうち, 化学療法非施行者の腎集積指数の平均値(0.61±0.01)よりも有意に高い腎集積指数を示したのは15例(71.4%)であった. 次に, 腎集積指数を用いて, 腎異常集積の出現とCDDP投与からスキャンまでの日数, CDDP投与量, 腎機能および年齢との関係について検討した. 腎集積指数とCDDP投与からスキャンまでの日数との間には負の相関が得られ, CDDP投与早期に集積度が高く, 次第に減少する傾向を示した. 化学療法施行から17日以降は腎異常集積は認められなかった. また, 腎集積指数と腎機能の間にも相関が得られた. しかし, 腎集積指数とCDDP投与量および年齢との間には明らかな相関は得られなかった. 以上より, CDDP投与と骨シンチグラムの間隔が腎異常集積に最も重要な因子であると考察された. |
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| Practice | 臨床医学：一般 |
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| Keywords | Renal accumulation index, CDDP chemotherapy, 99mTc-MDP, Hot kidneys, BUN. |
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| English |
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| Title | Analysis of Contributing Factors with High Renal Uptake of 99mTc-MDP after Anti-Cancer Chemotherapy Including Cisplatin |
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| Subtitle | - Original Articles - |
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| Authors | Tachio SATO*, Seiro YOSHIOKA*, Yuko OGATA**, Yoshinao ABE*, Jutaro TAKAHASHI*, Kenji YAMADA**, Shuichi ONO*, Hiroshi FUKUDA* |
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| Authors(kana) | |
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| Organization | *Department of Nuclear Medicine and Radiology, Institute of Development, Aging and Cancer, Tohoku University, **Department of Radiology, Sendai Kosei Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 33 |
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| Number | 11 |
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| Page | 1221-1226 |
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| Year/Month | 1996/11 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | We studied the effect of anti-cancer chemotherapy including cis-platin (CDDP) on renal high uptake of 99mTc-MDP using renal accumulation index (RAI) which was defined as a ratio of the densities between kidneys and lumbar bodies. We analyzed 21 cases who received bone scintigraphy within 30 days after chemotherapy. High RAIs were observed in 15 cases (71.4%). We compared the relationship between the RAI and time interval of CDDP administration and bone scintigraphy, total dose of CDDP, BUN and age. High RAIs were inversely related to the time interval and no patient showed high RAI when bone scintigraphy were studied later than 17 days after chemotherapy. BUN level were related to RAI. But, dose of CDDP and ages were unlikely responsible for the RAI values in this study. We summarized that high renal uptake of 99mTc-MDP was likely to be due to short time interval after chemotherapy. |
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| Practice | Clinical medicine |
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| Keywords | Renal accumulation index, CDDP chemotherapy, 99mTc-MDP, Hot kidneys, BUN. |
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