| Japanese |
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| Title | 99mTc-ECD SPECTを用いたacetazolamide負荷前後の非侵襲的局所脳血流量測定 - 脳血管障害例における検討, 測定手技簡略化の検討も含めて - |
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| Subtitle | 《原著》 |
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| Authors | 竹内亮*, 松田博史**, 阪原晴海***, 小西淳二*** |
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| Organization | *西神戸医療センター内科・核医学診断部, **国立精神・神経センター武蔵病院放射線診療部, ***京都大学医学研究科核医学・画像診断学 |
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| Journal | 核医学 |
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| Volume | 33 |
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| Number | 11 |
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| Page | 1213-1220 |
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| Year/Month | 1996/11 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」脳血管障害を有する36例に対し, 99mTC-ECDを用い, 1回のRIアンギオグラフィとそれに引き続くacetazolamide(以下Acz)負荷前後の2回の連続するSPECT撮像を施行した(Acz群). RIアンギオグラフィからPatlak plotを応用して算出した平均脳血流量(mCBF)と負荷前後の大脳平均SPECT countを用いて, 定性SPECT画像に対しLassen補正を行い, Acz負荷前後の定量画像を作製した. 8例の脳血管障害を有する患者に対し, 同一の手技でAczの代わりに生理的食塩水を用いたPlacebo群では, 負荷後のmCBFは前値の98±5%であり, Acz群では前値の124±15%であった. 本法により動脈採血を行うことなく脳血流量を非侵襲的に算出した定量画像は, 定性画像に比しAczの負荷効果をより客観的に判定可能であり, 脳循環予備能を評価する簡便な方法と考えられる. |
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| Practice | 臨床医学：一般 |
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| Keywords | 99mTc-ECD, SPECT, Acetazolamide, CBF. |
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| English |
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| Title | Noninvasive Quantitative Measurements of Regional Cerebral Blood Flow Using Technetium-99m-L, L-ECD SPECT Activated with Acetazolamide |
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| Subtitle | - Original Articles - |
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| Authors | Ryo TAKEUCHI*, Hiroshi MATSUDA**, Harumi SAKAHARA***, Junji KONISHI*** |
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| Authors(kana) | |
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| Organization | *Department of Internal Medicine & Division of Nuclear Medicine, Nishi-Kobe Medical Center, **Division of Radiology, National Center Hospital for Mental, Nervous, and Muscular Disorders, NCNP, ***Department of Nuclear Medicine and Diagnostic Imaging, Kyoto University Graduate School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 33 |
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| Number | 11 |
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| Page | 1213-1220 |
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| Year/Month | 1996/11 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | To evaluate noninvasive regional cerebral blood flow (CBF) measurements using technetium-99m-L, L-ethyl cysteinate dimer (99mTc-ECD), radionuclide angiography, resting-and acetazolamide-activating-SPECT studies were performed during about one hour. Forty-four cases with diagnosis of cerebral ischemic disorders were studied. For 36 cases (Group "Acz"), radionuclide angiography was performed immediately after intravenous bolus injection of 300 MBq of 99mTc-ECD, followed by the consecutive SPECT studies. In the midst of the first SPECT study, acetazolamide was administered. Just after the completion of the first SPECT study, another 300 MBq of 99mTc-ECD was added and the second SPECT study was started. For the remaining 8 cases (Group "Placebo"), physiological saline was administered instead of acetazolamide. Quantitative flow-mapping image was calculated from the qualitative SPECT image by the application of Patlak plot graphical analysis and Lassen's correction. Group "Placebo" showed no increase of mean CBF (mCBF) between the resting- and the placebo-challenged-SPECT image (2nd mCBF/1st mCBF; 98+-5%). Group "Acz" showed 124+-15% increase of mCBF under acetazolamide activation. By use of these quantitative flow-mapping images, acetazolamide-activated CBF increase was recognized clearly and easily. This noninvasive method is easy to perform and may be helpful to measure cerebral perfusion changes in the acetazolamide test. |
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| Practice | Clinical medicine |
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| Keywords | 99mTc-ECD, SPECT, Acetazolamide, CBF. |
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