| Japanese |
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| Title | 99mTc-ECD SPECTを用いた初期アルツハイマー型痴呆患者の脳血流量測定 |
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| Subtitle | 《原著》 |
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| Authors | 中野正剛*, 松田博史*, 宇野正威** |
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| Authors(kana) | |
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| Organization | *国立精神・神経センター武蔵病院放射線診療部, **国立精神・神経センター武蔵病院精神科 |
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| Journal | 核医学 |
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| Volume | 33 |
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| Number | 11 |
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| Page | 1197-1206 |
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| Year/Month | 1996/11 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」初期アルツハイマー型痴呆に99mTc-ECDを用いて, Patlak Plot法により非侵襲的に脳血流量を定量した. 対象は, 高齢者の正常コントロール11例と, NINCDS-ADRDAによりアルツハイマー型痴呆と診断された24例で, possible 10例, probable 14例, の2群に分けられた. mCBFは正常群に比べてpossible群は有意差がなかったが, probable群は有意に低下していた. rCBFは両側の海馬, 縁上回および角回で正常群に比べ, possible群, probable群で有意に低下していた. 下および中側頭回では正常群に比べてpossible群は有意差をみなかったが, probable群は有意差を認めた. 99mTc-ECD SPECTによる非侵襲的脳血流測定は, 初期のアルツハイマー型痴呆の診断にきわめて有用であると考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | 99mTc-ECD, SPECT, rCBF, Alzheimer's disease. |
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| English |
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| Title | Regional Cerebral Blood Flow Measurements Using 99mTc-ECD SPECT in Patients with Alzheimer's Disease (AD) in the Early Stage |
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| Subtitle | - Original Articles - |
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| Authors | Seigo NAKANO*, Hiroshi MATSUDA*, Masatake UNO* |
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| Authors(kana) | |
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| Organization | *Division of Radiology, **Department of Psychiatry, National Center Hospital for Mental, Nervous, and Muscular Disorders, NCNP |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 33 |
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| Number | 11 |
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| Page | 1197-1206 |
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| Year/Month | 1996/11 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | Regional cerebral blood flow (rCBF) measurements using a Patlak plot method and SPECT with 99mTc-ECD were performed in 10 patients with possible Alzheimer's disease (AD), 14 patients with probable AD, and 11 age-matched normal control subjects. The whole brain CBF for the probable group showed significant reduction to 37.2 ml/100 g/min as compared with the normal value of 42.1 ml/100 g/min, whereas the possible group did not show significant reduction of the whole brain CBF. In the possible and probable groups, rCBF values in the bilateral hippocampi, supramarginal gyri, angular gyri were lower than normal values. Moreover, in the probable group, rCBF values showed significant decrease in the superior, middle and inferior temporal gyri. The whole brain CBF and rCBF, especially in the bilateral hippocampal regions, showed significant positive correlation with the scale of MMSE and HDS-R. These results suggest that noninvasive rCBF measurements using 99mTc-ECD are quite useful for the early diagnosis of AD. |
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| Practice | Clinical medicine |
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| Keywords | 99mTc-ECD, SPECT, rCBF, Alzheimer's disease. |
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