| Japanese |
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| Title | 心電図同期併用の201TICl/99mTc-Tetrofosmin2核種同時心筋SPECTデータ収集 - 運動負荷心筋シンチグラフィ1回撮像法 - |
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| Subtitle | 《原著》 |
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| Authors | 汲田伸一郎*, 趙圭一*, 水村直*, 木島鉄仁*, 鳥羽正浩*, 山田丈士*, 隈崎達夫*, 佐野純子**, 草間芳樹**, 宗像一雄** |
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| Authors(kana) | |
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| Organization | *日本医科大学放射線科, **日本医科大学第一内科 |
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| Journal | 核医学 |
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| Volume | 33 |
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| Number | 11 |
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| Page | 1189-1196 |
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| Year/Month | 1996/11 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」虚血性心疾患45例を対象とし, 201TlCl(Tl)および99mTc-Tetrofosmin(TF)を用いた運動負荷心筋シンチグラフィ1回撮像法を施行し, その臨床的有用性につき検討を行った. 安静時の被験者にTl 111 MBqを静注, 20〜30分後より多段階漸増運動負荷を開始, 最大負荷時にTF 370 MBqの投与を行った. ついでTF投与60分後より心電図同期併用の2核種同時心筋SPECTデータを収集, 冠動脈造影結果に基づき視覚的罹患冠動脈枝評価を行ったところSensitivity 76%, Specificity 94%, Accuracy 85%と良好な成績が得られた. また心拍同期データをもとに解析した局所収縮能値Regional %WTは, 正常域(236セグメント), 非梗塞部虚血域(25セグメント), 梗塞部虚血域(63セグメント), 梗塞部非虚血域(36セグメント)にてそれぞれ17.6±7.2, 16.6±6.8, 12.7±6.1, 8.9±7.2(%)と梗塞の有無および梗塞部虚血の有無により差異を認めた. 本法は1回の撮像のみで検査を完了でき, 負荷像および安静時像の解剖学的一致が得られ, また同時に局所収縮能をも評価し得る臨床的に有用な検査手法であると考える. |
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| Practice | 臨床医学：一般 |
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| Keywords | 201TlCl, 99mTc-tetrofosmin, Exercise stress myocardial scintigraphy. |
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| English |
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| Title | ECG-Gated Dual-Isotope Myocardial SPECT with 201Tl and 99mTc-Tetrofosmin : Simultaneous Assessment of Stress/Rest Myocardial Perfusion and Left Ventricular Function |
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| Subtitle | - Original Articles - |
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| Authors | Shin-ichiro KUMITA*, Keiichi CHO*, Sunao MIZUMURA*, Tetsuji KIJIMA*, Masahiro TOBA*, Takeshi YAMADA*, Tatsuo KUMAZAKI*, Junko SANO**, Yoshiki KUSAMA**, Kazuo MUNAKATA** |
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| Authors(kana) | |
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| Organization | *Department of Radiology, **First Department of Internal Medicine, Nippon Medical School |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 33 |
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| Number | 11 |
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| Page | 1189-1196 |
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| Year/Month | 1996/11 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | ECG-gated dual-isotope acquisition protocol involving rest imaging with 201Tl and stress 99mTc-tetrofosmin (TF) SPECT was designed for the simultaneous assessment of rest/stress myocardial perfusion and rest ventricular systolic function. This study assessed the feasibility and diagnostic accuracy of this protocol. Forty-five patients underwent the dual-isotope SPECT protocol. Twenty minutes after resting injection of 111 MBq of 201Tl, 370 MBq of 99mTc-TF was administered at a peak exercise. The dual-isotope gated SPECT acquisition was performed 1 hour later. Then, the regional count increase rate (%WT) of 99mTc-TF from end-diastole to end-systole was calculated using an automated method which was developed for quantification of regional wall thickening based on circumferential profile analysis in our laboratory. Myocardial perfusion and contractility analysis was carried out using 8 segments of left ventricle with comparison of coronary angiographical findings. The sensitivity and specificity for the detection of diseased coronary vessels (>=75% stenosis) were 76% and 94%, respectively. Infarcted regions showing reversible defect had significantly greater % WT as compared with those with fixed defects (63 seg; 12.7+-6.1% vs. 36 seg; 8.9+-7.2%), p<0.01). In conclusion, this dual-isotope protocol has some advantages; i.e., shortening an examination time, having the exact registration of stress/rest perfusion, and simultaneous evaluation of resting regional wall thickening. |
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| Practice | Clinical medicine |
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| Keywords | 201TlCl, 99mTc-tetrofosmin, Exercise stress myocardial scintigraphy. |
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