| Japanese |
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| Title | 123I-IMP SPECTを用いたAutoradiography法による局所脳血流量定量における動脈血化静脈採血法の検討 |
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| Subtitle | 《技術報告》 |
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| Authors | 大西隆*, 矢野隆郎**, 中野真一***, 陣之内正史****, 長町茂樹****, Leo FLORES II****, 中原浩****, 渡邊克司**** |
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| Authors(kana) | |
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| Organization | *潤和会記念病院放射線科, **潤和会記念病院内科, ***潤和会記念病院脳神経外科, ****宮崎医科大学放射線科 |
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| Journal | 核医学 |
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| Volume | 33 |
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| Number | 10 |
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| Page | 1105-1109 |
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| Year/Month | 1996/10 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」123I-IMP SPECTを用いたARG法による局所脳血流量測定の動脈採血を動脈血化静脈採血で代替可能か検討した. 虚血性脳血管障害患者15例を対象に123I-IMP静注後, 橈骨動脈(10分後)および手背皮静脈(10分, 20分後)より採血を行った. 静脈採血側の手部はタオルにより加温し動脈血化を行った. 手背皮静脈採血による入力関数積分値の動脈採血に対する平均誤差は, 123I-IMP静注10分後で4.1±3%, 20分後で9.3±5.4%であった. 静注10分後の静脈/動脈放射能濃度比は0.96±0.025と, 1に近い値を示した. 以上より, 動脈血化手背皮静脈採血時刻はIMP静注10分後がよいと考えられた. また, この場合, 局所脳血流量は動脈採血に比べ平均3.6±2%過大評価されたが, 両者の間には良好な相関を認めた. ARG法において動脈採血は動脈血化手背皮静脈採血で代替可能と考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | 123I-IMP SPECT, rCBF, Autoradiography method, Arterialized venous blood sampling. |
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| English |
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| Title | The Quantitative Regional Cerebral Blood Flow Measurement with Autoradiography Method Using 123I-IMP SPECT : Evaluation of Arterialized Venous Blood Sampling as a Substitute for Arterial Blood Sampling |
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| Authors | Takashi OHNISHI*, Takao YANO*, Shinichi NAKANO*, Seishi JINNOUCHI**, Shigeki NAGAMACHI**, Leo FLORES II**, Hiroshi NAKAHARA**, Katsushi WATANABE** |
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| Authors(kana) | |
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| Organization | *Department of Radiology, Internal Medicine, and Neurosurgery, Junwa Memorial Hospital, **Department of Radiology, Miyazaki Medical College |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 33 |
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| Number | 10 |
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| Page | 1105-1109 |
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| Year/Month | 1996/10 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | The purpose of this study is validation of calibrating a standard input function in autoradiography (ARG) method by one point venous blood sampling as a substitute for that by one point arterial blood sampling. Ten and 20 minutes after intravenous constant infusion of 123I-IMP, arterialized venous blood sampling from a dorsal vein were performed on 15 patients having ischemic cerebrovascular disease. And arterial blood sampling from radial artery was performed 10 min after 123I-IMP infusion. The mean difference rates of integrated input function between calibrated standard input function by arterial blood sampling at 10 min and that by venous blood sampling were 4.1+-3% and 9.3+-5.4% at 10 and 20 min after 123I-IMP infusion, respectively. The ratio of venous blood radioactivity to arterial blood radioactivity at 10 min after 123I-IMP infusion was 0.96+-0.02. There was an excellent correlation between ARG method CBF values obtained by arterial blood sampling at 10 min and those obtained by arterialized venous blood sampling at 10 min. In conclusion, a substitution by arterialized venous blood sampling from dorsal hand vein for artery can be possible. The optimized time for arterialized venous blood sampling was 10 min after 123I-IMP infusion. |
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| Practice | Clinical medicine |
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| Keywords | 123I-IMP SPECT, rCBF, Autoradiography method, Arterialized venous blood sampling. |
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