Japanese
Title13C-acetate呼気試験による胃排出能の評価
Subtitle《原著》
Authors瓜田純久*, 成木行彦*, 西野執*, 小山博*, 中谷尚登*, 大塚幸雄*
Authors(kana)
Organization*東邦大学医学部第一内科
Journal核医学
Volume33
Number10
Page1083-1090
Year/Month1996/10
Article原著
Publisher日本核医学会
Abstract「要旨」13C-acetate呼気試験とアセトアミノフェン(APAP)法による胃排出試験を同時に59例に行い検討した. 方法は半流動体の試験食OKUNOS-A 200ml(200kcal)に13C-acetate 100mgとAPAP 20mg/kgを混入し, 早朝空腹時に坐位にて飲用させた. 呼気の採取は飲用前, 飲用後5, 10, 15, 20, 30, 40, 50, 60, 70, 80, 90分に行い, 呼気中の13CO2濃度を測定した. APAP法は15, 30, 45, 60分後に採血し, 血中APAP濃度を測定した. 13C-acetate呼気試験では64.6%が50-70分で呼気中の13CO2濃度がピークとなった. 血中APAP45分値は, ピーク時間80分以降の場合, 有意に低値となり, 逆に40分以下では有意に高値であり, ピーク時間の正常範囲は50-70分と思われた. 血中APAP 45分値は呼気中13CO2の30, 40分値と相関し, 呼気中13CO2濃度を胃排出の指標とする場合, 20-40分値が適していると考えられた. 13C-acetate呼気試験は採血さえも不要な無侵襲検査であり, 胃排出能の定性的評価法になりえると思われた.
Practice臨床医学：一般
Keywords13C-acetate breath test, Gastric emptying, Acetaminophen method.
English
Title13C-Acetate Breath Test for the Measurement of Gastric Emptying Rates
Subtitle- Original Articles -
AuthorsYoshihisa URITA, Yukihiko NARUKI, Mamoru NISHINO, Hiroshi KOYAMA, Naoto NAKATANI, Sachio OTSUKA
Authors(kana)
OrganizationFirst Department of Internal Medicine, Toho University School of Medicine
JournalThe Japanese Journal of nuclear medicine
Volume33
Number10
Page1083-1090
Year/Month1996/10
ArticleOriginal article
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
AbstractAlthough acetaminophen (APAP) method is widely used to evaluate the gastric emptying rates of liquids in Japan, patients need to take a large dose of APAP. A scintigraphic technique requires the gamma camera. In this present state we try to search for an alternative method, which is easy to perform and noninvasive for the patient. 13C-acetate breath test and APAP method were performed at the same time in 59 patients after overnight fasting. The liquid test meal OKUNOS-A (200 ml, 200 kcal), contained APAP (20 mg/kg) and 13C-acetate 100 mg was orally administered to the patient. Breath samplimg for 13CO2 measurements was obtained every 5 min up to 20 min and every 10 min up to 90 min. Blood sampling for plasma APAP concentration was collected 15, 30, 45, and 60 min after oral administration of the test meal. The time of 13CO2 peak excretion in 13C-acetate breath test was ranged from 50 to 70 min in 37 out of 59 patients. Plasma APAP concentration at 45 min in over 80 min group was significantly lower than in 50-70 min group. In contrast, that in under 40 min group was significantly higher. 13CO2 breath excretion at 30-40 min correlated with plasma APAP concentration at 45 min significantly. These results suggest that optimal smpling time of breath test is 20-40 min. In conclusion, 13C-acetate breath test is reliable as a qualitative analysis, easy to perform, and a noninvasive method without taking blood and radiation exposure for a measurement of gastric emptying rates.
PracticeClinical medicine
Keywords13C-acetate breath test, Gastric emptying, Acetaminophen method.

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