| Japanese |
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| Title | 99mTc-tetrofosmin負荷心筋シンチグラムの至適撮像条件の検討とブルズアイ正常ファイルの特徴 |
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| Subtitle | 《原著》 |
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| Authors | 中川晋*, 木村満*, 栗村勝則**, 五十嵐彰**, 大場泰幸** |
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| Organization | *東京都済生会中央病院循環器内科, **東京都済生会中央病院放射線科 |
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| Journal | 核医学 |
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| Volume | 33 |
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| Number | 10 |
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| Page | 1073-1082 |
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| Year/Month | 1996/10 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」tetrofosmin負荷心筋シンチの至適撮像条件と, 正常ファイルの特徴を検討した. 健常人15名ずつにトレッドミルおよびジピリダモール負荷を行い, 正面Planar像から心肝比を, SPECT像からブルズアイ正常ファイルを作成した. 201Tl像の標準値である心肝比1.2以上を目安とすると, 本製剤の至適撮像時期は, トレッドミルは負荷直後, ジピリダモールは40分以降と考えられた. ブルズアイ正常ファイルの比較では, % uptakeに経時的推移・収集時間・核種・負荷方法で差はみられなかった. 次にブルズアイ正常ファイルで, % uptakeのバラツキの程度(SD)を比較したところ, tetrofosmin正常ファイルは, 201Tl正常ファイルより, 下壁・側壁でのSDが小であった(ANOVA, p<0.02). tetrofosmin正常ファイルを運用する場合, 特に, 下壁・側壁でのSD低値を反映した同部位でのアーチファクト出現に注意する必要があり, また評価に際しては, SD閾値設定に工夫が必要である. |
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| Practice | 臨床医学：一般 |
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| Keywords | 99mTc-tetrofosmin, Biodistribution, Dipyridamole stress test, Bullseye normal file. |
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| English |
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| Title | Optimal Protocol for 99mTc-Tetrofosmin Myocardial SPECT Imaging with Exercise or Dipyridamole Stress Test and the Characteristics of Bullseye Normal File |
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| Subtitle | - Original Articles - |
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| Authors | Susumu NAKAGAWA*, Mitsuru KIMURA*, Katsunori KURIMURA*, Akira IGARASHI*, Yasuyuki OOBA* |
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| Authors(kana) | |
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| Organization | *Department of Cardiotogy, **Department of Radiology, Tokyo Saiseikai Central Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 33 |
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| Number | 10 |
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| Page | 1073-1082 |
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| Year/Month | 1996/10 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | To determine optimal protocol for 99mTc-tetrofosmin SPECT imaging, 30 normal volunteers underwent treadmill or dipyridamole stress test with 770 MBq of tetrofosmin injection. Anterior planar images were acquired every 10-15 minutes for calculating heart/liver ratio. SPECT images were also obtained every 30 minutes for generating Bullseye normal files. In analysis of spatial tracer distribution among normal files, myocardium in Bullseye plot was divided in 9 areas, where mean values of % tracer uptake were calculated and compared by analysis of variance (ANOVA). In those 9 areas, mean values of SD (SD mean) were also compared for predicting artificial blackout in the Bullseye plot among 3 standard normal files: dipyridamole-201Tl, dipyridamole-tetrofosmin (60 min post-injection), and treadmill-tetrofosmin (30 min post-injection). In planar image analysis, high initial uptake in the liver and its acceptable clearance were noted in dipyridamole stress test. Adequate heart/liver ratio was accomplished immediately after treadmill, but 40 minutes later after dipyridamole stress test. ANOVA analysis showed no statistical difference in the spatial % tracer uptake among normal files, irrespective of time after acquisition, data collection time, or difference of tracer. However, SD means in inferior and lateral area of treadmill-tetrofosmin file were significantly small compared to that of dipyridamole-201Tl normal file (p<0.02 by ANOVA). Thus, we conclude that optimal timing for tetrofosmin SPECT imaging is immediately after treadmill, but at least 40 minutes after dipyridamole stress test. In addition, we should also keep in mind that unexpected blackout may appear in inferior and lateral area, when applying our normal files for reference. |
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| Practice | Clinical medicine |
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| Keywords | 99mTc-tetrofosmin, Biodistribution, Dipyridamole stress test, Bullseye normal file. |
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