| Japanese |
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| Title | 心尖部肥大型心筋症にみる心電図陰性T波の機序 - 201Tlおよび123I-MIBG心筋SPECTによる検討 - |
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| Subtitle | 《原著》 |
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| Authors | 王瑛*, 滝川修*, 半田俊之介*, 畠山謙二**, 鈴木豊** |
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| Authors(kana) | |
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| Organization | *東海大学医学部内科学第一教室, **東海大学医学部放射線学教室 |
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| Journal | 核医学 |
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| Volume | 33 |
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| Number | 9 |
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| Page | 999-1004 |
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| Year/Month | 1996/9 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」心尖部肥大型心筋症でThallium 201(201Tl)およびiodine 123 metaiodobenzylguanidine(123I-MIBG)心筋single-photon emission computed tomography(SPECT)を行い心電図異常と心肥大および心筋交感神経活性の関連を検討した. 心電図陰性T波と心エコー図法による心肥大所見から診断した心尖部肥大型心筋症8例(AHCM群)と健常者7例を比較した. AHCM群では心電図左側胸部誘導にR波の高電位と陰性T波, ST低下をみた. 核医学検査では, 心エコー図で肥大のある心尖部と他の部位(前壁, 中隔および側壁)の取り込み比を求めた. AHCM群は健常群と比べ心尖部で201Tlの取り込み比が高かった. 123I-MIBGの取り込み比は低下の傾向をみた. 二つの核種の取り込み比の商(201Tl/123I-MIBG)は心筋症群で健常群に比べ高値を示した. 心尖部肥大型心筋症の肥大心筋では心筋交感神経活性が低下し, 心電図巨大陰性T波はこの活性低下を反映することが示唆された. |
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| Practice | 臨床医学：一般 |
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| Keywords | Apical hypertrophic cardiomyopathy, Myocardial sympathetic nerve, Thallium-201, 123I-metaiodobenzylguanidine, Giant negative T wave. |
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| English |
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| Title | The Mechanism of Giant Negative T Wave in Electrocardiogram in Patients with Apical Hypertrophic Cardiomyopathy : Evaluation with Thallium-201 and Iodine-123 Metaiodobenzylguanidine Myocardial Scintigraphy |
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| Subtitle | - Original Articles - |
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| Authors | Ying WANG*, Osamu TAKIGAWA*, Shunnosuke HANDA*, Kenji HATAKEYAMA**, Yutaka SUZUKI** |
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| Authors(kana) | |
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| Organization | *Section of Cardiology, Department of Medicine, **Department of Radiology, Tokai University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 33 |
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| Number | 9 |
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| Page | 999-1004 |
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| Year/Month | 1996/9 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | The aims of this study were to clarify the mechanism of giant negative T waves (GNT) in patients with apical hypertrophic cardiomyopathy (AHCM), using myocardial SPECT with thallium-201 (201Tl) and iodine-123 metaiodobenzylguanidine (123I-MIBG). Myocardial SPECT in 8 patients with AHCM, diagnosed with GNT in EKG and apical hypertrophy in echocardiogram, were compared with those in 7 normal subjects. The EKG in patients with AHCM showed tall R waves, GNT and ST segment depression in the left precordial leads. With the SPECT, the ratio of radioisotope activities apical ROI vs. other ROI (anterior, septal and lateral segments) were calculated. The ratio of 201Tl was high in AHCM, compared with that of normal subjects, suggested the increase in apical myocardial blood flow. The ratio of 123I-MIBG tended to be low in AHCM. The 201Tl/123I-MIBG ratio was high in the apical myocardium in AHCM, indicated low sympathetic nerve activities, though there was myocardial hypertrophy. We concluded that giant negative T waves in apical hypertrophic cardiomyopathy might be due to relatively low cardiac sympathetic nerve activities in apical myocardium with idiopathic hypertrophy. |
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| Practice | Clinical medicine |
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| Keywords | Apical hypertrophic cardiomyopathy, Myocardial sympathetic nerve, Thallium-201, 123I-metaiodobenzylguanidine, Giant negative T wave. |
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