Japanese
TitleIMP-SPECTによるアルツハイマー型痴呆患者の局所脳血流量についての定量的検討 - IMP ARG法の臨床応用 -
Subtitle《原著》
Authors越泰彦*, 北村伸*, 小宮山佐*, 酒寄修*, 駒場祐一*, 大山雅史*, 津金澤俊和*, 三品雅洋*, 石渡明子*, 増谷祐之*, 中澤勝*, 赫彰郎*
Authors(kana)
Organization*日本医科大学第一病院第二内科
Journal核医学
Volume33
Number9
Page991-998
Year/Month1996/9
Article原著
Publisher日本核医学会
Abstract「要旨」Iidaらにより開発された簡易な脳血流の定量法であるIMP ARG法と高解像度の頭部専用リング型SPECT装置を用いて, アルツハイマー型痴呆(DAT)患者37例の局所脳血流量(rCBF)を測定し, 臨床的有用性について検討した. 分布容積Vdおよび標準入力関数は, 正常ボランティア6例にdynamic studyを施行して得られた値の平均を用いた. IMP ARG法により測定されたDAT患者のrCBFは, 痴呆の重症度をよく反映しており, 長谷川式痴呆スケールの値とrCBFとの間の相関も前頭・側頭・頭頂葉皮質で有意なものであった. 本法は動脈血採血およびSPECT測定が1回のみでよく, 従来の方法に比べて簡便かつ患者に対する侵襲も軽度であり, 痴呆性疾患を有する患者の診断および経過観察を行う上で臨床的にきわめて有用と考えられた.
Practice臨床医学：一般
KeywordsDementia of Alzheimer type (DAT), Regional cerebral blood flow (rCBF), Single photon emission computed tomography (SPECT), IMP autoradiographic method (IMP ARG method), Distribution volume (Vd).
English
TitleA Quantitative Study of Regional Cerebral Blood Flow in Patients with Dementia of Alzheimer Type Using Single Photon Emission Computed Tomography - Clinical Application of the IMP Autoradiographic method (IMP ARG Method) -
Subtitle- Original Articles -
AuthorsYasuhiko KOSHI, Shin KITAMURA, Tasuku KOMIYAMA, Osamu SAKAYORI, Yuichi KOMABA, Masashi OHYAMA, Toshikazu TSUGANESAWA, Masahiro MISHINA, Akiko ISHIWATA, Hiroyuki SOYA, Masaru NAKAZAWA, Akiro TERASHI
Authors(kana)
OrganizationSecond Department of Internal Medicine, Nippon Medical School First Hospital
JournalThe Japanese Journal of nuclear medicine
Volume33
Number9
Page991-998
Year/Month1996/9
ArticleOriginal article
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
AbstractWe quantitatively measured regional cerebral blood flow (rCBF) in 37 patients with dementia of Alzheimer type (DAT) to investigate the clinical utilities of the N-isopropyl-p-[123I] iodoamphetamine autoradiographic method (IMP ARG method) that is a quantitative method more simplified and less invasive for IMP-SPECT developed by Iida et al. A given standard input function and a given value of distribution volume (Vd) used for the rCBF measurement of this method were calculated from the dynamic study by six normal volunteers. Mean values [SD] of rCBF (ml/100g/min) in the Cerebral Cortex were 49.0 [6.0] in the controls (n=20), 42.6 [5.9] in mild DAT group (n=14), 36.7 [5.5] in moderate DAT group (n=12), and 26.4 [7.5] in severe DAT group (n=11), respectively. These values were significantly different between each neighboring group. Moreover, the correlations between the score by the Hasegawa dementia scale (HDS-R) and each rCBF were significant in the temporal, parietal, and frontal cortex. These findings suggest that the rCBF measurement in IMP-SPECT using this method is useful for the diagnosis of the clinical severity in patients with DAT.
PracticeClinical medicine
KeywordsDementia of Alzheimer type (DAT), Regional cerebral blood flow (rCBF), Single photon emission computed tomography (SPECT), IMP autoradiographic method (IMP ARG method), Distribution volume (Vd).

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