| Japanese |
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| Title | 運動負荷時の99mTc-MIBI心筋摂取増加率の定量評価 - response rateの有用性 - |
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| Subtitle | 技術報告 |
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| Authors | 高橋和栄*, 竹石恭知**, 藤原里美**, 熱海裕之**, 阿久津徹***, 駒谷昭夫***, 山口こう一*** |
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| Organization | *山形大学医学部放射線部, **第一内科, ***放射線科 |
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| Journal | 核医学 |
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| Volume | 33 |
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| Number | 7 |
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| Page | 779-784 |
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| Year/Month | 1996/7 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 運動負荷時の99mTc-MIBIの心筋摂取増加率の定量評価を行い, 冠動脈病変の検出を試みた. 運動負荷時に99mTc-MIBIを静注し, 90分後に運動負荷心筋SPECT像を撮像した. 撮像終了後, 99mTc-MIBIを再度静注し, 安静時心筋SPECT像を撮像した. そして安静時像から運動負荷像をサブトラクションし, 減衰補正, 投与量補正を行い補正安静時像を得た. 運動負荷による心筋集積増加の指標として, response rateを (運動負荷像 - 補正安静時像)/補正安静時像×100の式に従い, 各冠動脈領域毎に算出した. 正常冠動脈症例では, response rateは102%であった. 左前下行枝1枝病変の狭心症例では, 左前下行枝領域のresponse rateは21%と著明に低下していた. 99mTc-MIBIを用い, 運動負荷時の冠血流増加率の推定が可能であり, 冠動脈病変検出に有用と考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | Coronary artery disease, 99mTc-MIBI, Response rate, Coronary perfusion reserve. |
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| English |
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| Title | Quantitative Assessment of an Increase of Myocardial 99mTc-MIBI Accumulation During Exercise - Usefulness of Response Rate - |
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| Authors | Kazuei TAKAHASHI*, Yasuchika TAKEISHI**, Satomi FUJIWARA**, Hiroyuki ATSUMI**, Toru AKUTSU***, Akio KOMATANI***, Koichi YAMAGUCHI*** |
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| Authors(kana) | |
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| Organization | *Division of Radiology, **First Department of Internal Medicine, ***Department of Radiology, Yamagata University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 33 |
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| Number | 7 |
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| Page | 779-784 |
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| Year/Month | 1996/7 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | The increase of myocardial 99mTc-MIBI accumulation during exercise was evaluated quantitatively, and the feasibility of response rate as a noninvasive marker of coronary stenosis was tested. Myocardial perfusion imaging with 99mTc-MIBI during exercise and at rest was performed in patients with suspected coronary artery disease. A dose of 296 MBq of 99mTc-MIBI was injected intravenously at maximal treadmill exercise, and myocardial image was obtained 90 min later (1st image). Then, 740 MBq of 99mTc-MIBI was administered at rest, and myocardial image was repeated (2nd image). These images were corrected for a decay and injected dose, and the 1st image was subtracted from the 2nd image to obtain the rest image. An increase of myocardial accumulation of 99mTc-MIBI during exercise was defined as (exercise image-rest image)×100/rest image (response rate). A response rate of a patient with normal coronary artery was 102%, whereas a response rate in the area of severe coronary stenosis was 21% in a patients with angina pectoris. After successful PTCA to a stenosed coronary artery, a response rate increased to 75% in this patient. Coronary perfusion reserve during exercise can be assessed noninvasively by 99mTc-MIBI. Response rate of 99mTc-MIBI provides additional information to conventional perfusion imaging and may be a new marker of severity of coronary artery disease. |
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| Practice | Clinical medicine |
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| Keywords | Coronary artery disease, 99mTc-MIBI, Response rate, Coronary perfusion reserve. |
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