| Japanese |
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| Title | 99mTc-ECDによるacetazolamide負荷前後における非侵襲的局所脳血流量測定 |
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| Subtitle | 原著 |
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| Authors | 松田博史*, 中野正剛*, 田中正明** |
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| Organization | *国立精神・神経センター武蔵病院放射線診療部, **シーメンス旭メディテック株式会社 |
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| Journal | 核医学 |
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| Volume | 33 |
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| Number | 7 |
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| Page | 759-766 |
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| Year/Month | 1996/7 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 99mTc-ECDを用い, 採血なしで非侵襲的にDiamox負荷前後の局所脳血流量を連続して測定する方法を開発した. 99mTc-ECDの初回投与時にRIアンギオグラフィを行い, 脳と大動脈弓の時間放射能曲線のグラフ解析法によりbaselineの大脳平均血流量を算出した. その後, 1gのDiamoxを静注した後, 1回目のSPECTを行い, Lassenらの補正法を用いて局所脳血流量を算出した. 1回目のSPECT終了直後に99mTc-ECDを追加静注し, 2回目のSPECTを行った. 2回目のSPECT像から1回目のそれをサブトラクションすることにより, Diamox負荷後の像を得た. 負荷前の大脳平均血流量, 負荷前の大脳平均SPECTカウント, および投与量と撮像時間で補正したサブトラクション画像のSPECTカウントからLassenらの補正を用いることによりDiamox負荷後の大脳平均血流量を算出した. この値とサブトラクション画像を用いてLassenらの補正により負荷後の局所脳血流量を求めた. この方法の再現性を6人の患者で検討したところ, 大脳平均および局所脳血流量に関して変動係数はそれぞれ平均2.7%および3.5%と良好であった. さらに, 本法を9人の非脳血管性痴呆患者に応用したところ, 大脳平均脳血流量が有意に平均35.7%増加した. 本法は短時間で簡便にDiamox負荷前後の脳血流量測定を行うことが可能であり, 実用性が高い. |
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| Practice | 臨床医学：一般 |
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| Keywords | 99mTc-ECD, SPECT, rCBF, Diamox, Cerebral perfusion reserve. |
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| English |
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| Title | Noninvasive Regional Cerebral Blood Flow Measurements at Pre- and Post-Acetazolamide Test Using 99mTc-ECD |
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| Authors | Hiroshi MATSUDA*, Seigo NAKANO*, Masaaki TANAKA** |
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| Authors(kana) | |
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| Organization | *Division of Radiology, National Center Hospital for Mental, Nervous, and Muscular Disorders, NCNP, **Siemens-Asahi Medical Technologies |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 33 |
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| Number | 7 |
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| Page | 759-766 |
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| Year/Month | 1996/7 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | A technique for serial noninvasive cerebral blood flow measurements at pre- and post-acetazolamide (Diamox(R)) test was newly developed using 99mTc-ECD without blood sampling. Baseline mean cerebral blood flow (mCBF) was measured from graphical analysis of time activity curves for brain and aortic arch obtained from radionuclide angiography by injection of 370-555 MBq 99mTc-ECD. The first SPECT study was performed immediately after intravenous administration of 1 g of Diamox, then baseline regional cerebral blood flow (rCBF) was calculated using Lassen's correction algorithm. Immediately after the stop of the first SPECT study, additional 555-740 MBq of 99mTc-ECD was administered, thereafter the second SPECT study was started. Post-Diamox SPECT images were obtained by subtraction of the first baseline images from the second images. Using Lassen's algorithm, post-Diamox mCBF was estimated from the baseline mCBF, the baseline mean SPECT counts, and post-Diamox mean SPECT counts corrected for administered dose and imaging time. Post-Diamox rCBF was obtained from the post-Diamox mCBF and the post-Diamox mean SPECT counts using Lassen's algorithm. Coefficient variation was shown 2.7% and 3.5% : mCBF and rCBF, respectively in test-retest results in six patients without Diamox administration. Nine demented patients without vascular disorders showed significant mCBF increase of 35.7% on the average by post-Diamox. In conclusion, this simplified method is practically useful for measuring CBF at pre- and post-Diamox test within short period of time without any blood sample. |
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| Practice | Clinical medicine |
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| Keywords | 99mTc-ECD, SPECT, rCBF, Diamox, Cerebral perfusion reserve. |
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