| Japanese |
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| Title | 123I-BMIPP心筋シンチを用いた慢性心不全患者の左心機能評価に関する研究 |
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| Subtitle | 原著 |
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| Authors | 渡邊浩毅*, 関谷達人**, 鶴岡高志*, 舩田淳一**, 宮川正男***, 熊野正士*** |
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| Organization | *県立南宇和病院内科, **国立療養所愛媛病院内科, ***放射線科 |
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| Journal | 核医学 |
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| Volume | 33 |
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| Number | 7 |
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| Page | 743-751 |
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| Year/Month | 1996/7 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 心不全患者を対象に, 心エコーより得た左心機能 (%FS) と123I-15-(p-iodophenyl)-3(R,S)-methylpentadecanoic acid (BMIPP) のプラナー像より得られた心筋摂取比, 心 / 縦隔比 (H / M), 心 / 肺比 (H / Lu), 心 / 肝比 (H / Li)とを比較することにより, 心不全患者の左心機能をその病因・病態の違いから検討し, BMIPP心筋シンチの心機能評価に対する有用性を検討した. 対象は心不全を既往にもつ48例 (拡張型心筋症17例, 虚血性心疾患16例, 弁膜症5例, 肥大型心筋症4例, 高血圧4例, 変性疾患2例 : 男性34例, 女性14例) で絶飲食下で安静時BMIPP心筋シンチを施行した. %FSとはH / M (r=0.67, p<0.001) とH / Lu (r=0.49, p<0.001) とが有意な相関を示したが, H / Li (r=0.12, p=0.42) と心筋摂取比 (r=0.03, p=0.86) は有意な相関を示さなかった. しかし, 心筋摂取比を左室重量で除した値 (心筋摂取比 / 左室重量) ではr=0.59, p<0.001と有意な相関を示した. 相関の高かったH / M, 心筋摂取比 / 左室重量について, さらに症例数の多かった拡張型心筋症と虚血性心疾患において比較・検討したが, 後者に比し前者は相関が低く, 心筋虚血だけでなくその他の因子の関与が示唆された. 以上より, 心不全患者の左心機能評価にBMIPP心筋シンチは有用で, 特に疾患により心筋への取り込みに差を生じたことから, 心不全の病態を考えた上での左心機能評価に, 有用な指標になる可能性が示唆された. |
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| Practice | 臨床医学：一般 |
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| Keywords | 123I-BMIPP, Left ventricular function, Chronic heart failure, Myocardial uptake. |
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| English |
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| Title | Usefulness of 123I-BMIPP Myocardial Scintigraphy for Evaluation of the Left Ventricular Function in Patients with Chronic Heart Failure |
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| Authors | Kouki WATANABE*, Michihito SEKIYA**, Takashi TSURUOKA*, Junichi FUNADA**, Masao MIYAGAWA***, Seishi KUMANO*** |
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| Authors(kana) | |
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| Organization | *Division of Internal Medicine, Minamiuwa Ehime Prefectural Hospital, **Division of Internal Medicine, Ehime National Hospital, ***Division of Radiology, Ehime National Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 33 |
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| Number | 7 |
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| Page | 743-751 |
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| Year/Month | 1996/7 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | We examined the relationship between free fatty acid metabolism using 123I beta-methyl-iodophenylpentadecanoic acid (BMIPP) and cardiac function in patients with chronic heart failure (CHF). Cardiac free fatty acid metabolism was evaluated by the heart to mediastinum ratio (H / M), the heart to lung ratio (H / Lu), the heart to liver ratio (H / Li) and the myocardial uptake ratio (MUR) obtained from the planar imaging. Cardiac function was evaluated by the percent of fractional shortening (%FS) and the amount of left ventricular mass (LVmass) calculated with echocardiography. The study included 34 male and 14 female subjects of CHF with mean age of 61+-9 years ; dilated cardiomyopathy (DCM) : n=17, ischemic heart disease (IHD) : n=16, valvular disease : n=5, hypertrophic cardiomyopathy : n=4, hypertension : n=4, amyloidosis : n=2. The correlations between indices of BMIPP uptake and those of echocardiography were as follows : H / M vs. %FS (r=0.67, p<0.01), H / Lu vs. %FS (r=0.49, p<0.01), H / Li vs. %FS (r=0.12, p=0.42), MUR vs. %FS (r=0.03, p=0.86) and MUR / LVmass vs. %FS (r=0.59, p<0.01). The correlation coefficient between H / M and MUR / LVmass in patients with IHD was higher than that in patients with DCM. In conclusion, BMIPP, in particular, is a useful tool for evaluating cardiac function in patients with CHF. |
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| Practice | Clinical medicine |
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| Keywords | 123I-BMIPP, Left ventricular function, Chronic heart failure, Myocardial uptake. |
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