Japanese
Titleバセドウ病の131I治療患者における副甲状腺機能亢進症 (hyperparathyroidism) の発症について (第2報)
Subtitle原著
Authors伊藤國彦*, 土屋武彦*, 杉野公則*, 村田紀**
Authors(kana)
Organization*伊藤病院, **千葉県がんセンター疫学研究部
Journal核医学
Volume33
Number7
Page737-742
Year/Month1996/7
Article原著
Publisher日本核医学会
Abstract「要旨」 前報において, バセドウ病で治療をうけた患者について, 血中Ca値, parathyroid hormone値の測定を行い, 131I治療患者にhyperparathyroidism (HPT) を発生させる可能性があることを報告した. そこで, 伊藤病院においてバセドウ病で治療を行った患者で, HPTを発病した19例 (131I治療 : 15例, 抗甲状腺剤治療 : 4例) を中心として, 対照となる母集団, それぞれ233例と199例を用いて, 131I治療がHPT発症の要因となりうるか否かについて検討を行った. その結果, バセドウ病によって131I治療をうけた患者は, 抗甲状腺剤治療の患者よりHPTの発症例が多いこと, ならびに, 131I治療例では, 線量効果関係が認められた. また, 追跡期間が長く, 発症年齢も高いことが認められた. 以上のことから, 131Iによる治療は, HPT発生の要因となりうるが, 追跡期間, 発症年齢も重要な因子であることが示された.
Practice臨床医学：一般
KeywordsHyperparathyroidism, Basedow disease, 131I therapy, Anti-thyroid drug therapy.
English
TitleAn Evaluation of the Incidence of Hyperparathyroidism after 131I Treatment for Basedow Disease (Part II)
Subtitle
AuthorsKunihiko ITO*, Takehiko TSUCHIYA*, Kiminori SUGINO*, Motoi MURATA**
Authors(kana)
Organization*Ito Hospital, **Division of Epidemiology, Chiba Cancer Center Research Institute
JournalThe Japanese Journal of nuclear medicine
Volume33
Number7
Page737-742
Year/Month1996/7
ArticleOriginal article
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
AbstractThe authors reported in a previous paper that 131I treatment for Basedow disease tends to increase in development of hyperparathyroidism (HPT) after therapy, from results showing that the measurement of levels of parathyroid hormone and calcium in the blood showed higher levels in the 131I-treated (RI) group than in the anti-thyroid drugs (ATD) group after therapy for Basedow disease. In the present work, the incidence of HPT was studied in patients with HPT that developed after treatment with 131I and / or ATD for Basedow disease at Ito Hospital. Fifteen of nineteen HPT patients had been treated with 131I and the other four had been treated with ATD. Basedow patients of the same age and sex with HPT and treated in the same year at Ito Hospital were selected as the control population for this study. The populations were 223 cases treated with 131I and 199 cases with ATD. The incidence of HPT in the RI and ATD groups was 6.7 percent and 2.0 percent, respectively. The incidence in the RI group was apparently higher than that in the ATD group. The average latent periods in the RI group and in the ATD group were 13.5 years and 4.1 years respectively. In the RI group 11 cases underwent follow-up periods of more than 10 years and 4 cases were followed up for less than 10 years. For the ATD group 3 of 4 HPT cases were followed up for less than 3 years. In the population the average follow-up periods for the RI group and the ATD group were 5.9 years and 5.3 years respectively. A relationship between radiation dose and development of HPT was demonstrated in these 15 cases of HPT. These findings suggest that 131I treatments for Basedow disease may result in development of hyperparathyroidism but the length of the follow-up period may also be an important factor in the incidence.
PracticeClinical medicine
KeywordsHyperparathyroidism, Basedow disease, 131I therapy, Anti-thyroid drug therapy.

【全文PDF】