| Japanese |
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| Title | 11C-Benztropineによるムスカリン作動性アセチルコリン受容体の脳内分布の解析 - 解剖学的標準化を用いて - |
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| Subtitle | 原著 |
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| Authors | 小野修一*1, 川島隆太*1, 伊藤浩*1, 小山眞道*1, 後藤了以*1, 井上健太郎*1, 佐藤和則*1, 藤原竹彦*2, 目黒謙一*3, 谷内一彦*4, 佐々木英忠*5, 井戸達雄*2, 伊藤正敏*2, 福田寛*1 |
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| Authors(kana) | |
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| Organization | *1東北大学加齢医学研究所機能画像医学研究分野, *2サイクロトロンRIセンター, *3医学部高次機能障害学分野, *4第一薬理学, *5老人内科 |
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| Journal | 核医学 |
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| Volume | 33 |
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| Number | 7 |
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| Page | 721-727 |
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| Year/Month | 1996/7 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 11C-Benztropine (BZT) を用いたPET画像に解剖学的標準化を適用し, 健常者7例におけるムスカリン性アセチルコリン受容体の脳内分布を解析した. 11C-BZT静注後のダイナミックPET画像と, 動脈血漿中の未変化体の時間放射能曲線より, Patlak plotの傾きの計算画像を作成した. その計算画像をHBAシステムを用いて解剖学的に標準化し, 平均値・標準偏差値画像を作成して, ROI解析した. それらによると, 後頭葉, 基底核への高い結合が見られ, 本法は今後の応用に有用な解析法と思われた. |
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| Practice | 臨床医学：一般 |
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| Keywords | Brain, Benztropine, Muscarinic acetylcholine receptor, PET. |
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| English |
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| Title | Regional Distribution of the Muscarinic Cholinergic Receptor in the Human Brain Studied with 11C-Benztropine and PET Using an Anatomical Standardization Technique |
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| Authors | Shuichi ONO*1, Ryuta KAWASHIMA*1, Hiroshi ITO*1, Masamichi KOYAMA*1, Ryoi GOTO*1, Kentarou INOUE*1, Kazunori SATO*1, Takehiko FUJIWARA*2, Kenichi MEGURO*3, Kazuhiko YANAI*4, Hidetada SASAKI*5, Tatsuo IDO*2, Masatoshi ITO*2, Hiroshi FUKUDA*1 |
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| Authors(kana) | |
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| Organization | *1Department of Nuclear Medicine and Radiology, Institute of Development, Aging, and Cancer, Tohoku University, *2Cyclotron R1 Center, Tohoku University, *3Section of Neuropsychology, Graduate School of Medicine, Tohoku University, *4Department of Pharmacology I, *5Department of Geriatric Medicine, School of Medicine, Tohoku University |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 33 |
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| Number | 7 |
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| Page | 721-727 |
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| Year/Month | 1996/7 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | We measured regional distribution of the muscarinic cholinergic receptor in the normal human brain with 11C-benztropine (BZT) and positron emission tomography (PET) using an anatomical standardization technique. Seven normal volunteers who gave informed consents were involved in this study. Immediately after intravenous injection of 11C-BZT into the subjects, we started dynamic PET scanning and serial frequent arterial blood sampling. Analyses of plasma metabolites were also performed at selected time points and plasma time activity curves (TAC) of unmetabolized ligand were generated. From these PET and TAC data, we obtained Patlak plot slope calculation images. Using the HBA (human brain atlas) system, the Patlak plot slope calculation image of each subject was transformed into the shape of the standard brain. Mean and standard deviation (SD) calculation images were generated from those anatomically standardized images. On these mean and SD images, we placed regions of interest which were previously outlined on a MR image of the standard brain. From those data, we found the highest receptor distribution in the striatum and occipital cortex, as well as high distribution in the frontal, parietal, and temporal cortices, which were consistent with previous reports. These results suggested that anatomical standardization of PET receptor images with 11C-BZT will be useful for delineating the physiological or pathological alterations of the muscarinic cholinergic receptor in the human brain. |
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| Practice | Clinical medicine |
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| Keywords | Brain, Benztropine, Muscarinic acetylcholine receptor, PET. |
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