| Japanese |
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| Title | 潰瘍性大腸炎における99mTc-HMPAO白血球イメージングの臨床的有用性に関する検討 |
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| Subtitle | 原著 |
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| Authors | 斉藤泰博*, 油野民雄*, 高塩哲也*, 秀毛範至*, 綾部時芳**, 野村昌史**, 高後裕**, 石川幸雄***, 佐藤順一*** |
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| Organization | *旭川医科大学放射線科, **第三内科, ***放射線部 |
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| Journal | 核医学 |
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| Volume | 33 |
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| Number | 7 |
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| Page | 711-719 |
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| Year/Month | 1996/7 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 潰瘍性大腸炎と診断された11例を対象に, 99mTc-HMPAO-WBCを用いた炎症シンチグラフィの有用性について検討した. 病型は, 全大腸炎型10例, 左側大腸炎型1例であり, また, 臨床経過よりは再燃緩解型8例, 慢性持続型3例に分類される. 方法は, 作製した標識白血球200MBqを静注後, 1時間, 4時間および24時間の時点で撮像し, 検査は可能な限り治療前後に施行するものとした. 病変の検出能を病変の部位, 全身重症度および大腸の内視鏡的活動度との関連性で検討した. 白血球シンチグラフィの陽性正診率および陰性正診率は, 83.3%と85.7%であり, 内視鏡で観察した炎症の部位, 程度とよく一致していた. また, 全身的な炎症所見 (重症度) ともよく一致していた. 特に, 治療前後における効果判定とはきわめて良好な相関を示していた. 白血球シンチグラフィは非侵襲的かつ短時間に活動性の評価が可能であり, 潰瘍性大腸炎の診断および治療効果の判定にはきわめて有用な検査方法であると考えられた. 潰瘍性大腸炎の成因として白血球が深く関わっていることが示唆されており, 本法が病因を解明していく上にも今後, 大きな役割を果たしうるものと期待される. |
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| Practice | 臨床医学：一般 |
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| Keywords | Leukocyte imaging, Ulcerative colitis, Inflammatory bowel disease, Leukocyte scintigraphy. |
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| English |
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| Title | Clinical Evaluation of 99mTc-HMPAO Labeled Leukocyte Imaging in Ulcerative Colitis |
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| Authors | Yasuhiro SAITOH*, Tamio ABURANO*, Tetsuya TAKASHIO*, Noriyuki SHUKE*, Tokiyoshi AYABE**, Masashi NOMURA**, Yutaka KOHGO**, Yukio ISHIKAWA***, Junichi SATOH*** |
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| Authors(kana) | |
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| Organization | *Department of Radiology, **Third Department of Internal Medicine, ***Department of Clinical Radiology, Asahikawa Medical College |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 33 |
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| Number | 7 |
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| Page | 711-719 |
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| Year/Month | 1996/7 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | Inflammatory imaging using 99mTc-HMPAO-labeled mixed leukocytes was assessed for use in treating 11 cases diagnosed as ulcerative colitis : 10 cases with total colitis and 1 with left-sided colitis. They consisted of 8 patients with relapse-remitting type and 3 with chronic continuous type. Radionuclide abdominal images were obtained at 1 hr, 4 hr and 24 hr after intravenous injection of 200 MBq prepared 99mTc leukocytes. Obvious colonic activity noted at 4 hr served as the basis for positive comparative criterion in the present study. The diagnostic efficacy of radionuclide imaging was compared with endoscopic findings (based on Matts' classification) and the clinical manifestations as reference. The sensitivity and specificity of this imaging were 83.3% and 85.7%, respectively, these values being consistent with endoscopic findings and clinical manifestations at sites of disease activity. All of positive images changed to negative after treatment by leukocyte apheresis or glucocorticoid. Based on these results, 99mTc leukocyte imaging can be used to accurately evaluate severity and treatment response in ulcerative colitis. Leukocytes may be closely related to the pathogenesis of ulcerative colitis. |
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| Practice | Clinical medicine |
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| Keywords | Leukocyte imaging, Ulcerative colitis, Inflammatory bowel disease, Leukocyte scintigraphy. |
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