| Japanese |
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| Title | 123I-IMPが高集積を呈した神経膠腫の検討 - dynamic SPECTによる解析 - |
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| Subtitle | 原著 |
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| Authors | 周郷延雄*, 柴田家門*, 根本暁央*, 根本匡章*, 大石仁志*, 黒木貴夫*, 清木義勝*, 寺尾榮夫*, 高橋秀樹**, 高野政明**, 高橋宗尊*** |
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| Authors(kana) | |
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| Organization | *東邦大学医学部脳神経外科, **中央放射線部RI部門, ***島津製作所 |
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| Journal | 核医学 |
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| Volume | 33 |
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| Number | 7 |
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| Page | 695-704 |
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| Year/Month | 1996/7 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 123I-IMPが高集積を呈した神経膠腫4例 (anaplastic astrocytoma 2例, oligodendroglioma 2例) を経験し, 3例でdynamic SPECTによる早期の集積動態をとらえるとともに, 123I-IMPが低集積を示した神経膠腫と, CT, MRIおよび脳血管撮影所見を比較した. 123I-IMP高集積群のdynamic SPECTは, 投与直後から24秒毎, 計4分間のscan (initial uptake : IU), および2分毎計30分間のscanを施行した. 腫瘍部と対側脳における時間放射能曲線 (time activity curve : TAC) では, IUのTACですでに腫瘍部は高集積を示し, 血管撮影での著明な腫瘍陰影所見と一致していた. 2分毎30分間のTACでも腫瘍部では対側脳よりも早期に高集積を示した. また123I-IMP高集積群では, 123I-IMP低集積群とは異なり, 造影剤による増強効果はないか軽度であった. これらより腫瘍への123I-IMPの集積に腫瘍内血管床, 腫瘍血流量の増加, およびBBBの温存が関与しているものと考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | N-isopropyl-p-[123I]-iodoamphetamine, Glioma, Dynamic SPECT. |
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| English |
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| Title | High Uptake of N-Isopropyl-p-[123I]-Iodoamphetamine (123I-IMP) Demonstrated by Dynamic SPECT in Some Cases of Glioma |
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| Authors | Nobuo SUGOU*, Iekado SHIBATA*, Akio NEMOTO*, Masaaki NEMOTO*, Hitoshi OHISHI*, Takao KUROKI*, Yoshikatsu SEIKI*, Hideo TERAO*, Hideki TAKAHASHI**, Masaaki TAKANO**, Munehiro TAKAHASHI*** |
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| Authors(kana) | |
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| Organization | *Department of Neurosurgery, **Division of Nuclear Medicine, Section of Radiology, Toho University School of Medicine, ***Shimadzu Corporation |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 33 |
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| Number | 7 |
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| Page | 695-704 |
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| Year/Month | 1996/7 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | Selective high uptake of N-isopropyl-p-[123I]-iodoamphetamine (123I-IMP) in the brain tumors is not common, the mechanism of uptake in the brain tumor is not yet clearly understood. Among 26 cases of gliomas investigated by dynamic SPECT, 4 cases including 2 cases of anaplastic astrocytoma and 2 cases of oligodendroglioma, showed high uptake of 123I-IMP. New three detector type camera which enables us to investigate rapid successive scanning, was used in our study. In dynamic SPECT, 15 successive scans of 2 minutes interval were made for 30 minutes after administration of 123I-IMP. In addition, quick dynamic SPECT was tried in 2 cases, in which 10 quick successive scans of 24 seconds interval were investigated for initial 4 minutes immediately after administration of 123I-IMP. Radioactivity in the region of interest inside the tumor (T) and radioactivity of the corresponding site in the contralateral hemisphere (C) was measured respectively, and T / C ratio was calculated. Time course change of radioactivity (time activity curve : TAC) was analyzed in all cases. Radioactivity was always higher in the tumor and the average T / C ratio was 1.40. TAC showed rapid increase of 123I-IMP in the tumor during initial 2 minutes after administration and keeping its high plateau level for 30 minutes. Angiography in these cases revealed a remarkable tumor stain. On the other hand, these gliomas showed no or slight enhancement effect in CT or MRI. These findings are interpretable as that early high uptake of 123I-IMP in some gliomas is attributable to an increased vascular bed and blood flow with no or minimal derangement of blood brain barrier in these tumors. |
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| Practice | Clinical medicine |
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| Keywords | N-isopropyl-p-[123I]-iodoamphetamine, Glioma, Dynamic SPECT. |
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