| Japanese |
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| Title | N-isopropyl-p-[123I]iodoamphetamine (123I-IMP) SPECTによる局所脳血流の定量測定法の比較・検討 |
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| Subtitle | 技術報告 |
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| Authors | 大久保真樹*, 小田野行男**, 高橋誠***, 野口栄吉**, 大滝広雄**, 笠原敏文**, 羽田野政義** |
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| Authors(kana) | |
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| Organization | *新潟大学医療技術短期大学部診療放射線技術学科, **新潟大学医学部放射線科, ***精神科 |
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| Journal | 核医学 |
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| Volume | 33 |
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| Number | 6 |
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| Page | 647-654 |
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| Year/Month | 1996/6 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 123I-IMP SPECTによる局所脳血流 (rCBF) 定量法である, 1) 123I-IMP静注後5分間の持続動脈採血と5分時点でのSPECT画像を用いるmicrosphere法, 2) その持続動脈採血に代えて1点採血法を取り入れたmicrosphere+1点採血法, 3) 123I-IMP静注後40分時点でのSPECT画像を全脳カウント比により補正して用いるmicrosphere法に1点採血法を取り入れたconventional microsphere+1点採血法, 4) Table look-up法および5) functional IMP SPECTについて, その精度を比較・検討した. 2コンパートメントモデルに基づいて非線形最小二乗法によって求めたrCBFとの相関は, microsphere法 (r=0.940), microsphere+1点採血法 (r=0.885), functional IMP SPECT (r=0.882) の順に良く, いずれも回帰直線はy=xに近く偏りは少なかった. Table look-up法は, 相関は良く (r=0.859) ばらつきは少ないが, 過小評価となり, 特に高血流域でこの傾向が大きくなった. conventional microsphere+1点採血法はやや過大評価となる傾向がみられたが, 相関は良く (r=0.849) 回帰直線の傾きは最も1に近い値が得られた. また分布容積は, functional IMP SPECTでは良い相関 (r=0.785) が認められたが, Table look-up法では高値 (43.4±6.6ml/g) を示し相関は不良であった (r=0.287). 今回の検討は同一のデータを用いた非線形最小二乗法による値との比較であることから, Table look-up法がrCBFを過小評価しVdを過大評価する原因は, 散乱, 吸収に関わるSPECT装置の性能や123I-IMPの初回循環抽出率 (<1.0) などの影響ではなく, 標準入力関数あるいはその較正に伴う誤差の影響と考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | 123I-IMP, Regional cerebral blood flow, Microsphere model, Table look-up method, Functional IMP SPECT. |
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| English |
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| Title | Validation Study in Quantitative Measurement of Regional Cerebral Blood Flow Using N-Isopropyl-p-[123I]Iodoamphetamine (123I-IMP) and SPECT |
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| Subtitle | |
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| Authors | Masaki OHKUBO*, Ikuo ODANO**, Makoto TAKAHASHI***, Eikichi NOGUCHI**, Hiroh OHTAKI**, Toshifumi KASAHARA**, Masayoshi HATANO** |
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| Authors(kana) | |
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| Organization | *Department of Radiological Technology, College of Biomedical Technology, Niigata University, **Department of Radiology, Niigata University School of Medicine, ***Department of Psychiatry, Niigata University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 33 |
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| Number | 6 |
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| Page | 647-654 |
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| Year/Month | 1996/6 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | We validated following five methods to quantitate regional cerebral blood flow (rCBF) using 123I-IMP and SPECT ; 1) microsphere method, which is based on a microsphere model using the SPECT image at five minutes after 123I-IMP injection with continuous withdrawal of arterial blood, 2) microsphere+one-point sampling method, which is the same as the microsphere method except for using one-point sampling instead of continuous withdrawal, 3) conventional microsphere+one-point sampling method, which is the same as the microsphere+one-point sampling method except for using a later SPECT image corrected with the ratio of alteration of measured entire brain activity, 4) Table look-up method, which is based on a two-compartment model (influx ; K1 and outflux ; k2) using one arterial blood sample taken at 10 min and two SPECT images at 30 min and 180 min post-injection, and 5) functional IMP SPECT, which is based on the two-compartment model using one arterial blood sample taken at 5 min and two SPECT images at 30 min and 60 min post-injection. Those methods were applied to six patients with cerebral infarction and degenerative diseases, and rCBF results were compared with those estimated by nonlinear least squares fitting (NLLSF) analysis based on the two-compartment model. The rCBF values obtained by the microsphere method was best correlated with those by NLLSF analysis (r=0.940), followed by the microsphere+one-point sampling method (r=0.885) and the functional IMP SPECT (r=0.882). The table look-up method underestimated rCBF especially at the high flow level, however showed good correlation (r=0.859). The conventional microsphere+one-point sampling method overestimated rCBF, however showed good correlation (r=0.849). Distribution volume (Vd=K1/k2) was also estimated by both the table look-up method and the functional IMP SPECT. While values of Vd by the functional IMP SPECT were significantly correlated with those by NLLSF analysis (r=0.785), the table look-up method overestimated Vd (43.4+-6.6ml/g) and showed not good correlation (r=0.287). |
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| Practice | Clinical medicine |
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| Keywords | 123I-IMP, Regional cerebral blood flow, Microsphere model, Table look-up method, Functional IMP SPECT. |
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