Japanese
Title冠攣縮性狭心症における心筋障害の検討 - 123I-BMIPP心筋SPECTを用いて -
Subtitle原著
Authors阿部充伯*, 城忠文*, 原裕二*, 橋田啓*, 小山靖史*, 風谷幸男*
Authors(kana)
Organization*愛媛県立中央病院内科
Journal核医学
Volume33
Number6
Page599-606
Year/Month1996/6
Article原著
Publisher日本核医学会
Abstract「要旨」 冠攣縮性狭心症における123I-BMIPP心筋SPECTの有用性を検討した. 冠攣縮性狭心症患者20名に対し, 安静時123I-BMIPP, 運動負荷201Tl心筋SPECTおよび左室造影を施行し, その集積程度を定量化し, 左室駆出率や局所壁運動低下との関連を検討した. 123I-BMIPP集積低下は201Tl後期像よりも高度で, 局所壁運動指数や心筋虚血時期と有意な相関関係を認めた. 123I-BMIPP集積低下部位は, 冠攣縮部位の75%, 局所壁運動低下部位の75%に一致し, 201Tl後期像に比し高率に冠攣縮・左室壁運動低下を検出した. 冠攣縮部位に123I-BMIPP後期像で再分布を認めた症例は6例存在し, 同部位のwashout rateは他の部位より有意に低値であり, 壁運動低下度も高度であった. 以上より, 123I-BMIPP心筋SPECTは冠攣縮に伴う心筋障害を高率に検出でき, 冠攣縮性狭心症の診断および重症度の把握に有用である.
Practice臨床医学:一般
KeywordsVasospastic angina, 123I-BMIPP myocardial scintigraphy, Myocardial damage, Stunned myocardium.
English
TitleEvaluation of Myocardial Damage Using 123I-BMIPP Imaging in Patients with Vasospastic Angina
SubtitleOriginal Articles
AuthorsMitsunori ABE, Tadafumi JOH, Yuji HARA, Kei HASHIDA, Yasushi KOYAMA, Yukio KAZATANI
Authors(kana)
OrganizationDepartment of Internal Medicine, Ehime Prefectural Central Hospital
JournalThe Japanese Journal of nuclear medicine
Volume33
Number6
Page599-606
Year/Month1996/6
ArticleOriginal article
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
AbstractThe purpose of this study is to determine whether left ventricular dysfunction following coronary artery spasm by 123I-BMIPP myocardial imaging. To reveal the clinical efficacy of 123I-BMIPP SPECT, 20 patients with vasospastic angina were studied using resting, 3-hour delayed image with 123I-BMIPP and exercise, 3-hour delayed image with 201Tl SPECT. 123I-BMIPP uptake was decreased compared to 201Tl (discordant) in 12 patients (60%) and in 49/100 myocardial segments (49%). The extent and severity score in resting image with 123I-BMIPP were significantly larger than that in delayed image with 201Tl (p<0.01). In 123I-BMIPP SPECT, the severity score in the latest ischemia were significantly larger than that in others. The incidence of a complete agreement of decreased 123I-BMIPP uptake and coronary artery spasm was significantly higher (75%) than that in 201Tl (28%, p<0.01). Furthermore, compared to 201Tl uptake, decreased 123I-BMIPP uptake much more corresponded to reduced wall motion in 9 of patients with mismatching. The severity of regional wall motion abnormality was significantly correlated with severity score of 123I-BMIPP. Late redistribution in delayed image with 123I-BMIPP was seen in 6 patients. The regional washout rate and the severity of regional wall motion abnormality in 6 patients was significantly lower than that in others (p<0.05). Thus, metabolic abnormality assessed by 123I-BMIPP is well associated with left ventricular asynergy and spastic region in patients with vasospastic angina. In conclusion, 123I-BMIPP SPECT may sensitively delineate the impaired myocardium following coronary artery spasm, and it is very useful in diagnosing and estimating the severity of vasospastic angina.
PracticeClinical medicine
KeywordsVasospastic angina, 123I-BMIPP myocardial scintigraphy, Myocardial damage, Stunned myocardium.

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