| Japanese |
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| Title | 冠攣縮性狭心症における心筋障害の検討 - 123I-BMIPP心筋SPECTを用いて - |
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| Subtitle | 原著 |
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| Authors | 阿部充伯*, 城忠文*, 原裕二*, 橋田啓*, 小山靖史*, 風谷幸男* |
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| Organization | *愛媛県立中央病院内科 |
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| Journal | 核医学 |
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| Volume | 33 |
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| Number | 6 |
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| Page | 599-606 |
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| Year/Month | 1996/6 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 冠攣縮性狭心症における123I-BMIPP心筋SPECTの有用性を検討した. 冠攣縮性狭心症患者20名に対し, 安静時123I-BMIPP, 運動負荷201Tl心筋SPECTおよび左室造影を施行し, その集積程度を定量化し, 左室駆出率や局所壁運動低下との関連を検討した. 123I-BMIPP集積低下は201Tl後期像よりも高度で, 局所壁運動指数や心筋虚血時期と有意な相関関係を認めた. 123I-BMIPP集積低下部位は, 冠攣縮部位の75%, 局所壁運動低下部位の75%に一致し, 201Tl後期像に比し高率に冠攣縮・左室壁運動低下を検出した. 冠攣縮部位に123I-BMIPP後期像で再分布を認めた症例は6例存在し, 同部位のwashout rateは他の部位より有意に低値であり, 壁運動低下度も高度であった. 以上より, 123I-BMIPP心筋SPECTは冠攣縮に伴う心筋障害を高率に検出でき, 冠攣縮性狭心症の診断および重症度の把握に有用である. |
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| Practice | 臨床医学：一般 |
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| Keywords | Vasospastic angina, 123I-BMIPP myocardial scintigraphy, Myocardial damage, Stunned myocardium. |
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| English |
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| Title | Evaluation of Myocardial Damage Using 123I-BMIPP Imaging in Patients with Vasospastic Angina |
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| Subtitle | Original Articles |
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| Authors | Mitsunori ABE, Tadafumi JOH, Yuji HARA, Kei HASHIDA, Yasushi KOYAMA, Yukio KAZATANI |
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| Authors(kana) | |
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| Organization | Department of Internal Medicine, Ehime Prefectural Central Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 33 |
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| Number | 6 |
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| Page | 599-606 |
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| Year/Month | 1996/6 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | The purpose of this study is to determine whether left ventricular dysfunction following coronary artery spasm by 123I-BMIPP myocardial imaging. To reveal the clinical efficacy of 123I-BMIPP SPECT, 20 patients with vasospastic angina were studied using resting, 3-hour delayed image with 123I-BMIPP and exercise, 3-hour delayed image with 201Tl SPECT. 123I-BMIPP uptake was decreased compared to 201Tl (discordant) in 12 patients (60%) and in 49/100 myocardial segments (49%). The extent and severity score in resting image with 123I-BMIPP were significantly larger than that in delayed image with 201Tl (p<0.01). In 123I-BMIPP SPECT, the severity score in the latest ischemia were significantly larger than that in others. The incidence of a complete agreement of decreased 123I-BMIPP uptake and coronary artery spasm was significantly higher (75%) than that in 201Tl (28%, p<0.01). Furthermore, compared to 201Tl uptake, decreased 123I-BMIPP uptake much more corresponded to reduced wall motion in 9 of patients with mismatching. The severity of regional wall motion abnormality was significantly correlated with severity score of 123I-BMIPP. Late redistribution in delayed image with 123I-BMIPP was seen in 6 patients. The regional washout rate and the severity of regional wall motion abnormality in 6 patients was significantly lower than that in others (p<0.05). Thus, metabolic abnormality assessed by 123I-BMIPP is well associated with left ventricular asynergy and spastic region in patients with vasospastic angina. In conclusion, 123I-BMIPP SPECT may sensitively delineate the impaired myocardium following coronary artery spasm, and it is very useful in diagnosing and estimating the severity of vasospastic angina. |
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| Practice | Clinical medicine |
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| Keywords | Vasospastic angina, 123I-BMIPP myocardial scintigraphy, Myocardial damage, Stunned myocardium. |
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