| Japanese |
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| Title | 123I-IMPの分布容積を用いたSPECTによる脳機能診断 |
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| Subtitle | 原著 |
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| Authors | 小田野行男*, 大久保真樹**, 高橋誠*, 野口栄吉*, 大滝広雄*, 笠原敏文*, 羽田野政義*, 佐藤友彦*** |
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| Authors(kana) | |
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| Organization | *新潟大学医学部放射線科, **医療技術短期大学部診療放射線技術学科, ***島津製作所 |
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| Journal | 核医学 |
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| Volume | 33 |
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| Number | 6 |
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| Page | 579-586 |
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| Year/Month | 1996/6 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 1点動脈採血と2回のSPECTスキャンから123I-IMPの分布容積像を作成するMagic square法をプログラム化してSPECT装置のコンピュータに導入した. このプログラムでは分布容積像のほかに脳血流像 (K1像), k2像およびdelayed / early ratio像の計4種の機能画像を同時に作成し, 表示することができる. またそれらの数値データも得ることができる. 従来から言われている再分布現象を, 本法により分布容積というパラメータに変換することによって定量的に評価することが可能である. 分布容積は123I-IMPの脳内保持機能の程度を表すと考えられるので, この変数を用いた新たな脳機能診断法が可能である. |
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| Practice | 臨床医学：一般 |
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| Keywords | 123I-IMP, rCBF, SPECT, Redistribution, Distribution volume. |
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| English |
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| Title | A Functional Diagnostic Method by Measuring of Distribution Volume of 123I-IMP with SPECT |
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| Subtitle | Original Articles |
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| Authors | Ikuo ODANO*, Masaki OHKUBO**, Makoto TAKAHASHI*, Eikichi NOGUCHI*, Hiroh OHTAKI*, Toshifumi KASAHARA*, Masayoshi HATANO*, Tomohiko SATO*** |
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| Authors(kana) | |
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| Organization | *Department of Radiology, Niigata University School of Medicine, **Department of Radiological Technology, College of Biomedical Technology, Niigata University, ***Medical System Division, Research and Development Department, Shimadzu Co. |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 33 |
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| Number | 6 |
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| Page | 579-586 |
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| Year/Month | 1996/6 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | To measure distribution volume of 123I-IMP with one-point sampling of arterial blood and 2 times SPECT scans using the Magic square method (Rate constant square method), we introduced a program on a SPECT computer system. In this program four functional images ; distribution volume, CBF (K1), k2 and delayed / early ratio, and absolute values with S.D. are obtained on the computer. We have been using the program on daily SPECT studies. In this study we discussed the usefulness of the method. Redistribution phenomenon of 123I-IMP, which is not exactly enough investigated, can be transformed into a functional parameter, distribution volume. Since distribution volume represents an extent of retention of 123I-IMP in brain tissue, it can play an important role to evaluate functional activity in the brain and to diagnose cerebral diseases. |
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| Practice | Clinical medicine |
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| Keywords | 123I-IMP, rCBF, SPECT, Redistribution, Distribution volume. |
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