Japanese
Title99mTc - HMPAO, 99mTc - ECDとPatlak plot法を用いたAcetazolamide負荷による脳血管拡張能評価の問題点 - 健常者における123I - IMPとの比較 -
Subtitle短報
Authors牧野憲一*, 増田安彦**, 後藤聰*
Authors(kana)
Organization*旭川赤十字病院脳神経外科, **放射線部
Journal核医学
Volume33
Number5
Page551-555
Year/Month1996/5
Article報告
Publisher日本核医学会
Abstract「要旨」Acetazolamideによる血管反応性評価の脳血流トレーサによる違いを3種類(IMP, ECD, HMPAO)のトレーサを用いて4人の健常成人を対象として検討した. IMPはmicrosphere modelを, ECDおよびHMPAOはPatlak plot法を用いて血流値を算出した. acetazolamide負荷検査はacetazolamide 1 gを静脈内に投与した. IMPのmCBFの増加率は29.3±10.5%(Mean±SD)であり, ECDの10.4±3.9%(p<0.05)およびHMPAOの8.9±6.9%(p<0.02)に比べて有意に高かった. IMPのrCBFの増加率は30.8±13.4%であり, ECDの14.3±13%(p<0.001)およびHMPAOの8.7±14.8%(p<0.001)に比べ有意に高かった. Patlak plot法により求めたBPIの増加率はECDが26.4±14.3%, HMPAOが13.9±12.9%とECDの方が高い増加率を示したが, 有意差はなかった.
Practice臨床医学：一般
KeywordsAcetazolamide, 123I-IMP, 99mTc-ECD, 99mTc-HMPAO, Cerebral blood flow.
English
TitleComparison of Cerebral Vasoreactivity to Acetazolamide in Normal Volunteer among 123I - IMP, 99mTc - ECD and 99mTc-HMPAO
SubtitleShort Communication
AuthorsKenichi MAKINO, Yasuhiko MASUDA, Satoshi GOTOH
Authors(kana)
OrganizationDepartment of Neurosurgery and Radiology, Asahikawa Red Cross Hospital
JournalThe Japanese Journal of nuclear medicine
Volume33
Number5
Page551-555
Year/Month1996/5
ArticleReport
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
Abstract[Summary]We studied the difference in the cerebral vasoreactivity to acetazolamide among three cerebral blood flow tracers, N-isopropyl-p-123I-iodoamphetamine(123I-IMP), 99mTc-ethyl cysteinate dimer(99mTC-ECD), 99mTc-hexamethylpropylene amine oxime(99mTc-HMPAO). Subjects were 4 healthy male adult volunteers at ages respectively of 30, 30, 35 and 41 years. Each subject underwent SPECT total 6 times. The three tracers were each used in the tests during rest and during acetazolamide loading, which were performed on different days. At least three days were allowed to intervene between one test and another, and all tests were completed within 2 months. The blood flow was calculated on the microsphere model with 123I-IMP, and Patlak plot method with 99mTc-ECD and 99mTc-HMPAO, to perform quantitative assessment. In the acetazolamide loading test, 1g acetazolamide was intravenously administered, and each tracer was administered at 15 minutes after that. mCBF and BPI data on total 8 sides, one side representing the right or left side of each subject, were statistically analyzed. For rCBF, the region of interest was set up on the right and left sides of the frontal, temporal and occipital lobes on the slice passing through the third ventricle. The percent increase in mCBF with IMP was 29.3+-10.5%(Mean+-SD), significantly higher than 10.4+-3.9%(p<0.05)with ECD or 8.9+-6.9%(p<0.02)with HMPAO. The percent increase in rCBF with IMP was 30.8+-13.4%, significantly higher than 14.3+-13%(p<0.001)with ECD or 8.7+-14.8%(p<0.001)with HMPAO. The percent increase in rCBF with ECD was higher than that with HMPAO, but not significantly. The percent increase in BPI calculated by Patlak plot method with ECD(26.4+-14.3%)was higher than that with HMPAO(13.9+-12.8%), but not significantly. It has been pointed out that 99mTc-ECD and 99mTc-HMPAO underestimate blood flow in the high blood flow area, which seemed to account for the underestimation of acetazolamide reactivity. The extent of underestimation in the high blood flow area is less with 99mTc-ECD than with 99mTc-HMPAO, while the stability of the preparation under acetazolamide is maintained, which seemed to explain difference in the reactivity.
PracticeClinical medicine
KeywordsAcetazolamide, 123I-IMP, 99mTc-ECD, 99mTc-HMPAO, Cerebral blood flow.

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