| Japanese |
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| Title | 2コンパートメントモデル解析に基づく99mTc - MAG3と131I - OIHの薬物動態の比較 |
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| Subtitle | 原著 |
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| Authors | 秀毛範至*, 高塩哲也*, 佐藤順一**, 石川幸雄**, 斉藤泰博*, 山本和香子*, 油野民雄*, 水永光博***, 金子茂男***, 八竹直***, 小川裕二****, 菊池健次郎****, 笹嶋唯博*****, 久保良彦***** |
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| Authors(kana) | |
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| Organization | *旭川医科大学附属病院放射線科, **中央放射線部核医学部門, ***泌尿器科, ****第一内科, *****第一外科 |
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| Journal | 核医学 |
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| Volume | 33 |
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| Number | 5 |
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| Page | 513-520 |
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| Year/Month | 1996/5 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」99mTc-MAG3, 131I-OIHを同時投与した50例を対象に, 血液中の両トレーサの時間放射能データをもとに2コンパートメントモデル解析を施行した. 各モデルパラメータを両トレーサ間で比較した結果, 血液を含む中心コンパートメントから血管外組織を含む末梢コンパートメントへの移行速度定数, 分布容量, クリアランス(血漿クリアランス)において, 131I-OIHが99mTc-MAG3に比し有意に大きい値(p<0.01)を示した. 両トレーサ間での各パラメータの相関を検討した結果, いずれのパラメータ間にも有意な相関(p<0.0002)が認められ, 特にクリアランスにおいて良好な相関(r=0.891, p<0.0001)が認められた. しかし, クリアランス比(MAG3/OIH)と血清クレアチニン濃度との間には有意な負の相関(r=-0.363, p<0.01)が認められ, クリアランスの相関に及ぼす影響は小さいものの, GFR低下域ではクリアランス比が小さくなる傾向が示唆された. これらの結果から, 99mTc-MAG3と131I-OIHの薬物動態は異なるものの, クリアランスにおいては良好な相関が認められ, 99mTc-MAG3クリアランスは, 131I-OIHクリアランスに代わりうる腎機能指標であることが確認された. |
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| Practice | 臨床医学：一般 |
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| Keywords | 99mTc-MAG3, 131I-OIH, Pharmacokinetics. |
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| English |
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| Title | Pharmacokinetics of 99mTc - MAG3 and 131I - OIH : Comparative Study Based on 2 Compartment Model Analysis |
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| Subtitle | Original Articles |
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| Authors | Noriyuki SHUKE*, Tetsuya TAKASHIO*, Junichi SATO**, Yukio ISHIKAWA**, Yasuhiro SAITo*, Wakako YAMAMOTO*, Tamio ABURANO*, Mitsuhiro MIZUNAGA***, Shigeo KANEKO***, Sunao YACHIKU***, Yuji OGAWA****, Kenjiro KIKUCHI****, Tadahiro SASAJIMA*****, Yoshihiko KUBO***** |
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| Authors(kana) | |
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| Organization | *Department of Radiology, **Central Radiology Service, ***Department of Urology, ****First Department of Internal Medicine, *****First Department of Surgery, Asahikawa Medical College Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 33 |
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| Number | 5 |
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| Page | 513-520 |
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| Year/Month | 1996/5 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]We studied 50 patients with mild to moderate renal dysfunction to compare pharmacokinetics of 99mTc-MAG3 with that of 131I-OIH. After simultaneous bolus injection of both 99mTc-MAG3 and 131I-OIH, 8-point venous blood sampling was performed from 2 to 44 min post injection. Aliquoted plasma samples were counted for radioactivity along with the injected standard to obtain % injected dose/ml plasma for each tracer. Using obtained time-concentration data, classical 2 compartment model analysis was performed for both tracers to obtain various pharmacokinetic parameters, including distribution volumes(Vds), inter-compartmental rate constants, and plasma clearance. In these parameters, Vd of central compartment, Vd at steady state, central to peripheral inter-compartmental rate constant, and plasma clearance were significantly larger for 131I-OIH. In all parameters, significant correlation was found between 99mTc-MAG3 and 131I-OIH. The best correlation was seen in plasma clearance(r=0.891, p<0.0001). Plasma clearance ratio(99mTc-MAG3/131I-OIH), however, showed weak but significant negative correlation with serum creatinine, although this correlation was not likely to affect the overall correlation of clearance between 131I-OIH and 99mTc-MAG3. From these results, we comfirmed that 99mTc-MAG3 clearance could be used as an alternative to 131I-OIH clearance, although pharmacokinetic behavior of 99mTc-MAG3 was not exactly the same as that of 131I-OIH. |
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| Practice | Clinical medicine |
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| Keywords | 99mTc-MAG3, 131I-OIH, Pharmacokinetics. |
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