| Japanese |
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| Title | 123I - MIBGを用いた糖尿病例の無症候性心筋虚血と心臓交感神経障害の検討 |
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| Subtitle | 原著 |
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| Authors | 松尾信郎*, 高橋正行*, 吉田慎太郎*, 井上亨*, 中村保幸*, 三ッ浪健一*, 木之下正彦* |
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| Authors(kana) | |
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| Organization | *滋賀医科大学第一内科 |
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| Journal | 核医学 |
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| Volume | 33 |
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| Number | 5 |
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| Page | 493-499 |
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| Year/Month | 1996/5 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」労作性心筋虚血を有する狭心症患者38例と正常者23例に123I-MIBG111MBqを静注し15分後と3時間後にplanar像とSPECT像を撮影し, 無症候性心筋虚血(SMI)患者と有痛性の狭心症(AP)患者でMIBG集積の特徴を対比検討した. 正常者と比べてSMIにおけるH/Mは低値を, washout rateは高値を認めたが, 糖尿病患者の中でSMIとAPとの間では差を認めなかった. 糖尿病のあるSMIの前壁下壁比は全群中最も低値を示した(p<0.05). relative regional uptakeは糖尿病患者の中でSMIではAP例に比べて下壁にMIBGの取り込み低下が認められた(p<0.05). 糖尿病患者のSMIにおいては下壁におけるMIBGの集積低下が存在し, 心臓交感神経障害と糖尿病性SMIとの関連が示唆された. |
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| Practice | 臨床医学：一般 |
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| Keywords | 123I-metaiodobenzylguanidine(MIBG), Silent myocardial ischemia, Sympathetic innervation, Diabetes mellitus. |
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| English |
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| Title | Characteristics of Regional Sympathetic Innervation in Diabetic Patients with Silent Myocardial Ischemia Assessed by 123I - Metaiodobenzylguanidine Imaging |
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| Subtitle | Original Articles |
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| Authors | Shinro MATSUO, Masayuki TAKAHASHI, Shintaro YOSHIDA, Tohru INOUE, Yasuyuki NAKAMURA, Kenichi MITSUNAMI, Masahiko KINOSHITA |
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| Authors(kana) | |
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| Organization | First Department of Internal Medicine, Shiga University of Medical Science |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 33 |
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| Number | 5 |
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| Page | 493-499 |
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| Year/Month | 1996/5 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]The purpose of this study was to clarify any association between clinically detectable silent myocardial ischemia(SMI)and myocardial 123I-metaiodobenzylguanidine(MIBG)uptake. Subjects of this study were(1)patients with SMI with diabetes(n=15), (2)patients with angina pectoris with diabetes(n=15), (3)patients with SMI without diabetes(n=8)and(4)normal subjects(n=23). Subjects underwent planar and single photon-emission-computed tomography(SPECT)imaging 15 min and 3 hours after injection of 123I-MIBG. H/M ratio was significantly lower in diabetic SMI(2.1+-0.3)and non-diabetic SMI(2.3+-0.3)than control subjects(2.6+-0.3). The inferior-to-anterior wall count ratio(I/A)in diabetic SMI group was the lowest among all groups(p<0.05). A significant difference was observed in relative regional uptake in the inferior segment of the distal left ventricle between SMI and angina group in patients with diabetes mellitus(p<0.05). The decreased MIBG uptake in the inferior wall may be an important sign of cardiac sympathetic dysfunction, suggesting the abnormalities in cardiac nervous system play an important role in the mechanism of diabetic silent myocardial ischemia. |
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| Practice | Clinical medicine |
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| Keywords | 123I-metaiodobenzylguanidine(MIBG), Silent myocardial ischemia, Sympathetic innervation, Diabetes mellitus. |
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