Japanese
Title骨転移発見における血中I型コラーゲンC端テロペプチドの経時的測定の意義
Subtitle技術報告
Authors山本逸雄*, 三浦裕晃*, 木上裕輔*, 山村恭代*, 大田豊承*, 游逸明*, 山本裕子*, 森田陸司*
Authors(kana)
Organization*滋賀医科大学放射線科
Journal核医学
Volume33
Number4
Page423-429
Year/Month1996/4
Article報告
Publisher日本核医学会
Abstract「要旨」転移性骨腫瘍の診断における骨代謝マーカー測定の意義を43例の悪性腫瘍患者(うち41例は乳癌)の経過観察による縦断観察により検討した. 経過観察中骨転移が発症した全例において, 腫瘍マーカーの上昇とともに, 血中I型コラーゲンC端テロペプチド(ICTP)の上昇が認められた. また, 骨転移を起こさなかった症例においては, ICTP値の変動はほとんど認めなかった. さらに, 骨転移に対する治療により臨床状態と相関して血中ICTPは低下した. 対照の血中I型プロコラーゲンプロペプチドは鋭敏に変動せず, また腫瘍マーカーは転移の発症に際し鋭敏に変動したが, 骨転移以外の腫瘍の進展に際しても上昇し, 骨転移に特異的ではなかった. 血中ICTPは骨転移のマーカーとして, 特に悪性腫瘍患者の経過観察を行うときに有用であることが示唆された. 「I. はじめに」骨の代謝を特異的に反映する諸種の骨代謝マーカーが開発され, 骨粗鬆症や, 骨転移など各種疾患における骨代謝マーカーの測定の有用性が報告されている.
Practice臨床医学：一般
KeywordsBone metastasis, Collagen crosslink, C-terminal telopeptide of type I collagen, Biochemical marker.
English
TitleDetection of Bone Metastasis by Serial Measurement of C - Terminal Telopeptide of Type I Collagen in Patients with Malignancy
SubtitleTechnical Reports
AuthorsItsuo YAMAMOTO, Hiroaki MIURA, Yuusuke KIGAMI, Yasuyo YAMAMURA, Toyotsugu OHTA, Itsuaki YUU, Yuuko YAMAMOTO, Rikushi MORITA
Authors(kana)
OrganizationDepartment of Radiology, Shiga University of Medical Science
JournalThe Japanese Journal of nuclear medicine
Volume33
Number4
Page423-429
Year/Month1996/4
ArticleReport
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
Abstract[Summary]Measurements of biochemical markers specific to bone resorption are known to be useful in evaluation of skeletal metastasis. However, most of previous studies were performed cross-sectionally and sensitivity for detection of early bone metastasis was not satisfactory. Since basal levels of bone markers differ significantly individually, longitudinal studies would be preferable to evaluate small metabolic changes such as in early skeletal metastasis. Thus, we performed serial measurements of serum c-terminal telopeptide of type I collagen(ICTP), a bone resorption marker, in patients with malignancy and evaluated its clinical significances for detection of bone metastasis, comparing with measurements of propeptide of type I procollagen(PICP)and tumor markers. In total, 43 patients(41 of them are breast cancer), serial serum samples were obtained during 0.5 to 2.4 years(mean 1.4 years). In all of nine patients, who developed bone metastasis, serum ICTP level increased, and by successful treatment to the metastatic lesions, ICTP level decreased, while in some cases, tumor markers remained to be elevated. PICP was less sensitive and specific for detection of bone metastasis. Thus, serial measurement of ICTP is suggested to be useful for detection and evaluation of therapeutic responses in patients with bone metastasis.
PracticeClinical medicine
KeywordsBone metastasis, Collagen crosslink, C-terminal telopeptide of type I collagen, Biochemical marker.

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