| Japanese |
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| Title | 中枢性ベンゾジアゼピン受容体イメージング剤123I - イオマゼニルの第3相臨床試験 (第4報) - 脳血管障害における臨床的有用性の検討 - |
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| Subtitle | 技術報告 |
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| Authors | 鳥塚莞爾*1, 上村和夫*2, 融道男*3, 篠原幸人*4, 西村恒彦*5, 米倉義晴*6, 中川原譲二*7, 松田博史*8, 坂井文彦*9, 松田一己*10, 福山秀直*11, 森本清*12 |
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| Authors(kana) | |
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| Organization | *1福井医科大学(現 ; 京都大学名誉教授), *2秋田県立脳血管研究センター, *3東京医科歯科大学神経精神科, *4東海大学第五内科(神経内科), *5大阪大学トレーサ情報解析学講座, *6京都大学脳病態生理学講座(現 ; 福井医科大学高エネルギー医学研究センター), *7中村記念病院脳神経外科, *8国立精神神経センター武蔵病院放射線診療部, *9北里大学内科, *10国立療養所静岡東病院(てんかんセンター)脳神経外科, *11京都大学神経内科(現 ; 脳病態生理学講座), *12香川医科大学精神神経科 |
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| Journal | 核医学 |
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| Volume | 33 |
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| Number | 3 |
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| Page | 329-344 |
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| Year/Month | 1996/3 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」中枢性のベンゾジアゼピン受容体(BZR)に特異的に結合する123I-イオマゼニルSPECTの脳血管障害(CVD)の病態把握における有用性を明らかにするために, 投与後3時間像(後期像)と脳血流像を比較検討した. 脳梗塞例では塞栓症よりも血栓症の方が, また, 皮質枝梗塞例よりも穿通枝梗塞例の方が脳虚血領域での後期像の集積低下は軽度であった. さらに, 脳虚血が著しいほど, また, 循環予備能が著しく低下した領域では発症後の経過が長いほど後期像の集積が低下した. すなわち, 脳梗塞例では後期像での集積低下は脳虚血に伴う神経細胞障害を反映すると考えられた. 一方, 頭蓋内出血例では皮質血流低下領域での後期像の集積低下は軽度であり, そのうち被殻出血例では血流低下が著しいほど後期像の集積低下が著明であったことから, 血流低下は主として神経連絡路の遮断による遠隔効果によるものであり, 血流低下が著しい領域では神経細胞障害も生じうることが示唆された. 本剤は, 従来からの血流や循環予備能とは異なる神経細胞の生存性に関する情報を反映するものと考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | 123I-Iomazenil, Benzodiazepine receptor, Cerebrovascular disease, Cerebral blood flow, Single photon emission CT. |
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| English |
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| Title | A Phase 3 Clinical Trial of 123I - Iomazenil, a New Central - Type Benzodiazepine Receptor Imaging Agent (Part 4) - Report on Clinical Usefulness in Diagnosis of Cerebrovascular Diseases - |
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| Subtitle | Technical Reports |
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| Authors | Kanji TORIZUKA*1, Kazuo UEMURA*2, Michio TORU*3, Yukito SHINOHARA*4, Tsunehiko NISHIMURA*5, Yoshiharu YONEKURA*6, Jyoji NAKAGAWARA*7, Hiroshi MATSUDA*8, Fumihiko SAKAI*9, Kazumi MATSUDA*10, Hidenao FUKUYAMA*11, Kiyoshi MORIMOTO*12 |
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| Authors(kana) | |
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| Organization | *1Fukui Medical School(Currently Professor Emeritus, Kyoto University), *2Akita Research Institute for Brain and Blood Vessels, *3Department of Psychiatry, Tokyo Medical and Dental University, *4Department of Neurology, Tokai University, *5Department of Tracer Kinetics, Osaka University, *6Department of Brain Pathophysiology, Kyoto University(currently Biomedical Imaging Research Center, Fukui Medical School), *7Department of Neurosurgery, Nakamura Memorial Hospital, *8Department of Radiology, National Center Hospital for Mental, Nervous, and Muscular Disorders, NCNP, *9Department of Internal Medicine, Kitasato University, *10Department of Neurosurgery, National Epilepsy Center, Shizuoka-Higashi Hospital, *11Department of Neurology(currently Department of Brain Pathophysiology), Kyoto University, *12Department of Neuropsychiatry, Kagawa Medical School |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 33 |
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| Number | 3 |
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| Page | 329-344 |
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| Year/Month | 1996/3 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]Single photon emission computed tomography(SPECT)using 123I-Iomazenil(IMZ), a tracer which binds specifically to central-type benzodiazepine receptors, was performed in patients with cerebrovascular diseases(CVD)to determine the clinical significance of IMZ SPECT studies in evaluating the pathophysiology of CVD. IMZ SPECT images obtained three hours after administration of the tracer were compared with the images of cerebral blood flow(CBF)studies in 206 cases. In regions with decreased CBF, the uptake of IMZ was relatively preserved in patients with cerebral thrombosis in comparison with cerebral embolism, and in those with perforator branch infarction in comparison with cortical infarction. The uptake of IMZ decreased as a function of both the severity of the decrease in the CBF and the duration of illness in regions with a significantly decreased perfusion reserve. These results suggest that decreased IMZ binding in ischemic stroke reflects the neuronal damage caused by the cerebral ischemia. On the other hand, in patients with intracerebral hemorrhage, the cortical uptake of IMZ was relatively wellpreserved in regions with decreased CBF, and the decrease in the uptake of IMZ was more profound as a function of the decrease in the CBF, especially in cases of putaminal hemorrhage. These results also suggest that the decreased cortical CBF is a remote effect caused by a neuronal disconnection, and neuronal damage may occur in regions with severely impaired CBF. |
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| Practice | Clinical medicine |
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| Keywords | 123I-Iomazenil, Benzodiazepine receptor, Cerebrovascular disease, Cerebral blood flow, Single photon emission CT. |
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