| Japanese |
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| Title | 123I - IMPダイナミックSPECTと動脈一回採血を用いた脳血流および脳血液分配定数の定量法 |
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| Subtitle | 原著 |
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| Authors | 水村直*, 汲田伸一郎*, 隈崎達夫* |
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| Organization | *日本医科大学放射線科 |
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| Journal | 核医学 |
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| Volume | 33 |
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| Number | 3 |
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| Page | 251-259 |
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| Year/Month | 1996/3 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」123I-IMPダイナミックSPECTと一回動脈採血から局所脳血流量(rCBF)と脳血液分配定数(λ)の算出を試みた. 本法では, 横井らの考案したグラフプロット法に用いられている線型微分方程式を使って解析を行い, 入力関数には一回採血データにより較正して得られた標準入力関数を使用した. 正常志願者5例(25から29歳, 平均年齢26歳)に対して本法を施行し, 入力関数に標準入力関数を用いる際の条件として較正して得られた標準入力関数の積分関数と28回の動脈採血によって得られた真の入力関数の積分関数を用いた場合に両者の平均偏差が小さくなる積分区間上限値の時間帯(8分後から60分後まで)と較正する採血時間(4分から10分後の一点)を求めた. さらに本法の妥当性を検討するために, 算出されたそれぞれのCBF, λを比較したところ, それぞれ良好な相関(r=0.87 : p<0.001, r=0.72 : p<0.001)が認められた. 本法はCBFとともにλも簡便に算出可能であり, 臨床的に有用な手法と考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | 123I-IMP dynamic SPECT, Cerebral blood flow, Partition coefficient, Single arterial sampling, Standard input function. |
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| English |
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| Title | Quantitation of Cerebral Blood Flow and Partition Coeffcient Using 123I - IMP Dynamic SPECT with Single Arterial Blood Sampling |
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| Subtitle | Original Articles |
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| Authors | Sunao MIZUMURA, Shin-ichiro KUMITA, Tatsuo KUMAZAKI |
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| Authors(kana) | |
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| Organization | Department of Radiology, Nippon Medical School |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 33 |
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| Number | 3 |
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| Page | 251-259 |
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| Year/Month | 1996/3 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] A method base on the two-compartment model was developed to measure quantitative cerebral blood flow(CBF)and partition coefficient(λ)of IMP from dynamic SPECT and single arterial blood sampling. In this method, the linear differential equation of two-compartment model, Yokoi proposed, was employed and quantitative CBF and λ values were measured with the standard input function calibrated by single arterial sampling. The input function was derived from the standard input function scaled by a factor determined by the single arterial blood sample. This new technique was applied to 5 normal volunteers(Ages ranged from 25 to 29 yr. , average 26 yr. ). The optimal time to calibrate the standard input function in the individual study and optimal the period of the upper limit time to which input function is integrated from IMP administration for analysis of the equation were determined to minimize the difference between integration of the calibrated standard input function and of the individual input function. Minimization of the difference yields an optimal calibration time(4 to 10 min after IMP adminstration)and the period of the upper limit time(from 8 to 60 min after acquisition start). Comparison of CBF and λ values obtained by the graphical method using the calibrated standard data and individual input function were performed. It should be noted that CBF values were in good agreement between the two methods, respectively(r=0.92, p<0.01 ; r=0.72, p=0.01). This method is easy to estimate CBF and λ by only single arterial blood sampling and IMP dynamic SPECT, and useful for routine studies. |
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| Practice | Clinical medicine |
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| Keywords | 123I-IMP dynamic SPECT, Cerebral blood flow, Partition coefficient, Single arterial sampling, Standard input function. |
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