Japanese
TitleN - isopropyl - p - [123I] iodoamphetamine (123I - IMP) SPECTによる局所脳血流および分布容積の新しい定量測定法
Subtitle原著
Authors大久保真樹*, 小田野行男**, 高橋誠***, 野口栄吉**, 大滝広雄**, 笠原敏文**, 羽田野政義**
Authors(kana)
Organization*新潟大学医療技術短期大学部診療放射線技術学科, **新潟大学医学部放射線科, ***精神科
Journal核医学
Volume33
Number3
Page241-249
Year/Month1996/3
Article原著
Publisher日本核医学会
Abstract「要旨」123I-IMP静注後約1時間程度の検査で, 1回の動脈採血と2回のSPECT撮像により局所脳血流(rCBF)および分布容積(Vd)を定量測定する新しい方法(functional IMP SPECT)を開発した. あらかじめ調べた相関に基づき1点採血データから入力関数の積分値を推定し, さらに2コンパートメントモデル(influx ; K1=rCBF, outflux ; k2)に基づいて作成した関数を利用して, 2回のSPECT撮像によって得られたデータからK1とVd(=K1/k2)を算出する. 本法における統計誤差はK1の算出では平均約14.0%, Vdでは約17.2%と算定された. 臨床データを用いた検討では, 本法によって算出したK1とVdは, 非線形最小二乗法による2コンパートメントモデル解析によって求めた値と良好な相関を示し, K1の算出誤差は約8.0%, Vdは約11.2%となり, 臨床的には充分な精度と考えられfunctional IMP SPECTの妥当性が示唆された.
Practice臨床医学：一般
Keywords123I-IMP, Regional cerebral blood flow, Distribution volume, SPECT, Two-compartment model.
English
TitleA New Method for Measurement of Both Regional Cerebral Blood Flow and Distribution Volume Using N - Isopropyl -p- [123I] Iodoamphetamine (123I - IMP) and SPECT
SubtitleOriginal Articles
AuthorsMasaki OHKUBo*, Ikuo ODANO**, Makoto TAKAHASHI***, Eikichi NOGUCHI**, Hiroh OHTAKI**, Toshifumi KASAHARA**, Masayoshi HATANO**
Authors(kana)
Organization*Department of Radiological Technology, College of Biomedical Technology, Niigata University, **Department of Radiology, Niigata University School of Medicine, ***Department of Psychiatry, Niigata University School of Medicine
JournalThe Japanese Journal of nuclear medicine
Volume33
Number3
Page241-249
Year/Month1996/3
ArticleOriginal article
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
Abstract[Summary]We developed a new method(functional IMP SPECT)to quantitate both regional cerebral blood flow(rCBF)and distribution volume(Vd)using 123I-IMP and SPECT based on a 2-compartment model(influx ; K1=rCBF and outflux ; k2). This method requires one arterial blood sampling at 5 min after injection of the tracer and two SPECT scans at 30 min and 60 min. It takes approximately 60 min for total measurements. The integration of arterial input function is estimated by one blood sample taken at 5 min after injection of the tracer without octanol treatment, by using the correlation between one blood sample and the integration, which was obtained from studies on 25 subjects. With the value of integration, K1 and Vd are calculated from the data of two SPECT scans by using the mathematical functions based on the 2-compartment model, which were obtained from studies on 12subjects. In the practical range of K1(0.3-0.7 ml/g/min)and Vd(15-35 ml/g)given in the 2-compartment model, statistical errors of K1 and Vd obtained by the functional IMP SPECT were evaluated at approximately 14.0% and 17.2%, respectively. In clinical studies for eight subjects including two healthy volunteers, three patients with cerebral infarction and three patients with degenerative disease, K1 and Vd values estimated by the functional IMP SPECT were significantly correlated with those estimated by non-linear least squares fitting analysis based on the 2-compartment model, and the mean errors of K1 and Vd estimated by the functional IMP SPECT were approximately 8.0% and 11.2% respectively, suggesting the validity of the new method. We conclude that the functional IMP SPECT is clinically useful because of the accuracy, less-invasiveness and convenience.
PracticeClinical medicine
Keywords123I-IMP, Regional cerebral blood flow, Distribution volume, SPECT, Two-compartment model.

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