| Japanese |
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| Title | 肝動注療法における薬剤分布評価のための99mTc - MAAを用いた肝動脈血流シンチグラフィ - continuous slow infusionとpulsatile infusionとの比較検討 - |
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| Subtitle | 原著 |
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| Authors | 片山通章*, 小須田茂*, 横山久朗*, 草野正一* |
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| Authors(kana) | |
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| Organization | *防衛医科大学校放射線科 |
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| Journal | 核医学 |
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| Volume | 33 |
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| Number | 3 |
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| Page | 233-240 |
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| Year/Month | 1996/3 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」肝動注療法を行っている21例に対して肝内薬剤分布を評価するため99mTc-MAA 111MBqをカテーテルより手動にて緩徐に連続動注(1ml/分)し, シンチグラフィを撮像した. 全26検査中42%(11検査)で不均一分布がみられた. これらは層流効果による影響と考えられたので11例(15検査)に対してパルス状にRIを注入し, 肝内RI分布の変化を比較検討した. パルス状に注入した場合, 連続注入時と比べ13%(2/15)にRI集積の改善がみられた. また全26検査中12%にカテーテル先端の変位により肝へのRI分布がみられず, 肝外臓器へのRI集積も23%にみられた. また血流変更術を行った4例中3例において不均一分布がみられた. 99mTc-MAA動注シンチグラフィは肝内薬剤分布の評価をする上で有用であり, また肝外臓器への薬剤分布による副作用を防止するのにも役立つと考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | Liver neoplasm, 99mTc-MAA, Intraarterial infusion, Drug delivery, Pulsatile infusion. |
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| English |
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| Title | Hepatic Arterial Perfusion Scintigraphy with 99mTc - MAA for Assessment of the Hepatic Distribution of Drugs Given by Intrahepatic Arterial Infusion |
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| Subtitle | Original Articles |
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| Authors | Michiaki KATAYAMA, Shigeru KOSUDA, Hisaaki YOKOYAMA, Shoichi KUSANO |
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| Authors(kana) | |
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| Organization | Department of Radiology, National Defense Medical College |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 33 |
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| Number | 3 |
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| Page | 233-240 |
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| Year/Month | 1996/3 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]Twenty-six hepatic arterial perfusion studies using 99mTc-MAA were carried out in 21 patients who underwent hepatic arterial infusion chemotherapy. Inhomogenous perfusion of the liver area supplied by the artery in which the catheter was placed was seen in 11(42%)of 26 studies, which may be caused by poor mixing of drug with blood at infuion site. To evaluate whether pulsed arterial infuion reduces this phenomenon, 99mTc-MAA was injected with pulsatile infusion in 15 studies. Improved RI distribution of the liver was obtained in 2 of 15 studies with pulsatile infusion. Extrahepatic perfusion was noted in 6(23%)of 26 studies. Displaced catheter was demonstrated in 3(12%)of 26 studies. Despite the attempts to correct the arterial abnormalities to ensure homogenous perfusion of the liver in 4 patients with anatomic variants, inhomogenous perfusion was seen in 3 of 4 patients. Hepatic arterial perfusion scintigraphy by 99mTc-MAA has advantages for assessing intrahepatic distribution of the chemotherapeutic agents, in addition to helping to avoid clinical complications caused by extrahepatic perfusion. |
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| Practice | Clinical medicine |
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| Keywords | Liver neoplasm, 99mTc-MAA, Intraarterial infusion, Drug delivery, Pulsatile infusion. |
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