| Japanese |
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| Title | IMP - ARG法による局所脳血流量の正常値 - マイクロスフェア法との比較 - |
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| Subtitle | 短報 |
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| Authors | 伊藤浩*, 石井清**, 木下俊文**, 小山真道**, 川島隆太*, 小野修一*, 福田寛* |
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| Authors(kana) | |
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| Organization | *東北大学加齢医学研究所加齢脳神経部門機能画像医学研究分野, **仙台市立病院放射線科 |
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| Journal | 核医学 |
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| Volume | 33 |
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| Number | 2 |
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| Page | 175-178 |
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| Year/Month | 1996/2 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」IMPによる脳血流量(CBF)の簡便な測定法として最近開発されたARG法によるCBFの正常値を, 男性健常者10名(平均29.8±6.1歳)を対象に測定し, 同時に測定したマイクロスフェア法によるCBFと比較した. ARG法による脳内各領域ごとのCBFは, 小脳, 橋, 視床, 大脳基底核, 前頭葉, 側頭葉, 頭頂葉, 後頭葉の各皮質域, 半卵円中心でそれぞれ, 41.7±9.4, 31.1±5.0, 40.7±9.7, 41.5±10.0, 38.2±9.2, 39.0±9.4, 41.9±10.6, 38.7±8.0, 30.0±7.7ml/100ml/min(±S. D. )であった. これらのうち半卵円中心以外のCBFは過去に報告されたPETによる値よりも低値を示し, この原因としてIMPの初回循環抽出率がH215Oのそれに比べ小さいことが考えられた. また, 理論に反してARG法によるCBFよりもマイクロスフェア法によるCBFが高値を示したが, マイクロスフェア法におけるSPECTデータの算出法に原因があると考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | IMP, ARG method, CBF, Normal value. |
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| English |
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| Title | Normal CBF Values by the ARG Method Using IMP SPECT : Comparison with a Conventional Microsphere Model Method |
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| Subtitle | Short Communication |
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| Authors | Hiroshi ITO*, Kiyoshi ISHII**, Toshifumi KINOSHITA**, Masamichi KOYAMA*, Ryuta KAWASHIMA*, Shuichi ONO*, Hiroshi FUKUDA* |
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| Authors(kana) | |
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| Organization | *Department of Nuclear Medicine and Radiology, Division of Brain Sciences, Institute of Development Aging and Cancer, Tohoku University, **Department of Radiology, Sendai City Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 33 |
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| Number | 2 |
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| Page | 175-178 |
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| Year/Month | 1996/2 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]N-isopropyl-p[123I]iodoamphetamine(IMP)has been used as a flow tracer for SPECT, and measurement of cerebral blood flow(CBF)using IMP has been performed by conventional microsphere model method(MS method). Recently, the ARG method for measuring CBF by using IMP with one SPECT scan and one point blood sampling has been developed. This method was based on two-compartment model. In the present study, normal CBF values were measured in ten male healthy subjects(mean age+-S. D. : 29.8+-6.01, age range : 23-41)by the ARG and the MS methods. The mean CBF values(+-S. D. )for the ARG method in which the Vd value was assumed to be 50ml/ml were 41.7+-9.4, 31.1+-5.0, 40.7+-9.7, 41.5+-10.0, 38.2+-9.2, 39.0+-9.4, 41.9+-10.6, 38.7+-8.0 and 30.0+-7.7 ml/100ml/min in the cerebellum, pons, thalamus, basal ganglia, frontal, temporal, parietal, occipital lobe cortex and centrum semiovale, respectively. The mean CBF values for the MS method were 46.8+-8.4, 375+-5.6, 45.8+-8.6, 46.5+-8.9, 43.7+-8.3, 44.4+-8.7, 46.8+-9.3, 44.3+-7.3 and 36.3+-8.1ml/100ml/min, respectively. The mean CBF values in the cerebral cortex region for the ARG method were lower than those previously reported by PET. This would be caused by low first-pass extraction fraction of IMP compared with oxygen-15 labeled water. The mean CBF values for the MS method were higher than those for the ARG method against previous studies. As reasons for this, errors in estimation of the SPECT brain counts at 8 min in the MS method were considered. |
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| Practice | Clinical medicine |
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| Keywords | IMP, ARG method, CBF, Normal value. |
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