| Japanese |
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| Title | 99mTc - GSAによる肝胆道腫瘍例の肝予備能評価 - 高ビリルビン血症の影響と局所肝予備能 - |
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| Subtitle | 原著 |
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| Authors | 呉勁*, 石川演美**, 武田徹**, 佐藤始広***, 福永潔***, 轟健**, 奥村敏之**, 畠山六郎***, 板井悠二** |
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| Authors(kana) | |
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| Organization | *筑波大学医学研究科, **臨床医学系, ***附属病院 |
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| Journal | 核医学 |
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| Volume | 33 |
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| Number | 2 |
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| Page | 161-168 |
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| Year/Month | 1996/2 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」70例の肝, 胆道腫瘍患者を対象として, 99mTc-GSAによる肝全体の予備能の評価法に, 血清総ビリルビン値の上昇がどのような影響を与えるか検討を行った. また, SPECT像とCT所見を比較検討した. その結果, (1)肝細胞癌群(肝硬変合併例を含む)では, LHL15はICG15, 血清総ビリルビン値によく一致して, 中等度以上肝予備能障害例が65.4%に見られた. (2)胆道癌群では, 胆道閉塞(完全あるいは不完全性)例が多く, ICG15と血清総ビリルビン値の間によい相関が見られた. しかし, LHL15とICG15および血清総ビリルビン値との乖離が見られ, LHL15はICG15のように高ビリルビン血症に修飾されず, 黄疸例においても信頼性の高い肝予備能指標として有用と考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | 99mTc-galactosyl serum albumin(99mTc-GSA), Hepatic scintigraphy, Hepatic functional imaging, Hyperbilirubinemia, Global and regional reserved hepatic function. |
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| English |
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| Title | Evaluation of Reserved Hepatic Function in Patients with Hepatobiliary Tumor by 99mTc - GSA : Effect of Hyperbilirubinemia and Usefulness of Regional Reserved Hepatic Functional Imaging |
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| Subtitle | Original Articles |
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| Authors | Jin WU*, Nobuyoshi ISHIKAWA*, Tohoru TAKEDA*, Motohiro SATO*, Kiyoshi FUKUNAGA***, Takeshi TODOROKI*, Toshiyuki OKUMURA**, Rokurou HATAKEYAMA**, Yuji ITAI* |
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| Authors(kana) | |
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| Organization | *Institute of Clinical Medicine, University of Tsukuba, **Department of Radiology, ***Department of Surgery, Tsukuba University Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 33 |
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| Number | 2 |
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| Page | 161-168 |
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| Year/Month | 1996/2 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]The evaluation of the reserved hepatic function was performed by 99mTc-galactosyl serum albumin(99mTc-GSA)in seventy patients with hepatobiliary tumor. The dynamic study was performed to evaluate global reserved hepatic function following the intravenous bolus injection of 99mTc-GSA, and the hepatic single photon emission computed tomography(SPECT)was obtained to assess the regional reserved hepatic function. The functional hepatic index(LHL15)was derived from liver time-activity data, and it was compared with serum total-bilirubin level, serum albumin level and plasma disappearance rate of indocyanine green(ICG15). In the patients with hepatocellular carcinoma, LHL15 value agreed well with ICG15 value, serum total-bilirubin level, and serum albumin level. Moderate or severe hepatic dysfunction was observed at 65.4% of these patients. In the patients with cholangiocellular carcinoma, a discrepancy of LHL15 value and ICG15 value was observed. Increment of the ICG15 value was correlated with that of the serum total-bilirubin level, whereas the correlations was not observed between the LHL15 value and the serum total-bilirubin level. These results indicate that 99mTc-GSA scintigraphy can evaluate the reserved hepatic function without the embellishment of jaundice. This method is useful for assessing the global and regional reserved hepatic function. |
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| Practice | Clinical medicine |
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| Keywords | 99mTc-galactosyl serum albumin(99mTc-GSA), Hepatic scintigraphy, Hepatic functional imaging, Hyperbilirubinemia, Global and regional reserved hepatic function. |
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