| Japanese |
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| Title | radiosurgery後における転移性脳腫瘍およびその周囲脳での循環動態変化 - 123I - IMP dynamic SPECTを用いて - |
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| Subtitle | 原著 |
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| Authors | 周郷延雄*, 柴田家門*, 根本暁央*, 根本匡章*, 串田剛*, 御任明利*, 大石仁志*, 黒木貴夫*, 寺尾榮夫*, 高野政明**, 高橋秀樹** |
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| Organization | *東邦大学脳神経外科, **中央放射線部RI部門 |
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| Journal | 核医学 |
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| Volume | 33 |
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| Number | 2 |
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| Page | 123-130 |
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| Year/Month | 1996/2 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」転移性脳腫瘍のradiosurgery後の腫瘍, 浮腫および腫瘍近傍脳での循環動態を123I-IMPを用いたdynamic SPECTにより検討した. 対象は12例で, 照射前, 後1, 7, 30日にSPECTを施行した. 0-5分の加算画像を用いて, 各ROIにおける平均カウント数/ピクセルを求め, これを腫瘍同側小脳の平均カウント数/ピクセルで除した(count ratio : 以下CR). 照射前のCRを1.0とし, 照射後の変化率(relative changes of CR : 以下rCR)を算出した. 腫瘍部のrCRは, 照射後で変化はなく, 浮腫部, および腫瘍近傍脳部では照射前に比較し, 照射7日後[1.434±0.409(p<0.05), 1.248±0.228(p<0.05)(Mann-Whitney test)], 30日後[1.359±0.245(p<0.01), 1.301±0.287(p<0.01)]に増加した. またCT上の腫瘍最大直径は1か月後で変化なく, 2か月後で有意な縮小を認めた[0.744±0.227(p<0.02)]. radiosurgeryは腫瘍周囲組織の血流量が照射7日後より改善しており, 早期から効果を期待できる治療法であると考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | N-isopropyl-p-[123I]-iodoamphetamine, Dynamic SPECT, Radiosurgery, Metastatic brain tumor, Regional cerebral blood flow. |
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| English |
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| Title | Changes of Regional Perfusion in Metastatic Brain Tumor and Peritumoral Area after Radiosurgery : A Study by 123I - IMP Dynamic SPECT |
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| Subtitle | Original Articles |
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| Authors | Nobuo SUGOU*, Iekado SHIBATA*, Akio NEMOTO*, Masaaki NEMOTO*, Tsuyoshi KUSHIDA*, Toshiaki MITOU*, Hitoshi OHISHI*, Takao KUROKI*, Hideo TERAO*, Masaaki TAKANO**, Hideki TAKAHASHI** |
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| Authors(kana) | |
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| Organization | *Department of Neurosurgery, **RI Department of Radiology, Toho University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 33 |
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| Number | 2 |
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| Page | 123-130 |
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| Year/Month | 1996/2 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]Changes of regional perfusion in the tumor, peritumoral edematous area and juxtatumor brain after radiosurgical treatment for metastatic brain tumor were investigated by dynamic SPECT using 123I-IMP. The SPECT was performed in 12 patients before and 1, 7 and 30 days after stereotactic irradiation. A region of interest(ROI)was selected each in the tumor, peritumoral edematous area, juxtatumor brain and ipsilateral cerebellum. Radioactivity in each ROIs was counted on early SPECT based on dynamic SPECT from 0 to 5 minutes. Mean count/pixel in each ROIs was divited by mean count/pixel in the ROI of the ipsilateral cerebellum and its value was designated as a count ratio(CR). Assuming the pre-treatment CRs are 1.0, relative changes of post-treatment CRs investigated. rCR in the tumor did not show any significant change after radiosurgical treatment. rCR in the edematous area and the juxtatumor brain increased at 7 days after irradiation [Mean+-SD 1.434+-0.409(p<0.05), 1.248+-0.228(p<0.05)by Mann-Whitney test] and at 30 days [1.359+-0.245(p<0.01), 1.301+-0.287(p<0.01)] respectively. Computed tomography revealed no change in the maximum diameter of the tumor at 1 month after irradiation but a significant reduction in the diameter [0.744+-0.227(p<0.02)] at 2 months. Early improvement of regional cerebral blood flow in the juxtatumor areas after radiosurgery suggested that radiosurgery could be effective treatment for metastatic brain tumor. |
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| Practice | Clinical medicine |
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| Keywords | N-isopropyl-p-[123I]-iodoamphetamine, Dynamic SPECT, Radiosurgery, Metastatic brain tumor, Regional cerebral blood flow. |
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