| Japanese |
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| Title | 99mTc-ECD SPECTによる正常脳血流像の作成 - 解剖学的標準化による評価 - |
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| Subtitle | 短報 |
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| Authors | 川島隆太*, 小山真道*, 伊藤浩*, 吉岡清郎*, 佐藤和則*, 小野修一*, 後藤了以*, 佐藤多智雄*, 福田寛* |
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| Organization | *東北大学加齢医学研究所機能画像医学研究分野 |
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| Journal | 核医学 |
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| Volume | 33 |
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| Number | 1 |
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| Page | 69-72 |
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| Year/Month | 1996/1 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」本研究の目的は99mTc-ECDの脳への正常分布パターンを明らかにすることである. 10名の正常被験者(年齢36〜63歳 : 男性8名, 女性2名)を対象にして, 99mTc-ECD脳SPECT像を撮像した. 被験者のX線CT像とコンピュータ化脳図譜システム(HBA : Human Brain Atlas)を利用して, それぞれの被験者のSPECT像を解剖学的に標準化し, 平均SPECT像を作成した. 99mTc-ECD平均SPECT像において, 後頭葉の内側面に非常に強い集積を認めた. 99mTc-ECDのヒト脳への集積パターンは, 99mTc-HMPAOのSPECT像や15O標識二酸化炭素ポジトロンCT像のパターンとは異なっており, 本剤の集積パターンは単純に局所脳血流を反映するだけではないことが考察された. |
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| Practice | 臨床医学：一般 |
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| Keywords | 99mTc-ECD, SPECT, Human brain, Cerebral perfusion, Anatomical standardization. |
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| English |
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| Title | Normal Cerebral Perfusion of 99mTc-ECD Brain SPECT - Evaluation by an Anatomical Standardization Technique - |
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| Authors | Ryuta KAWASHIMA, Masamichi KOYAMA, Hiroshi ITO, Seiro YOSHIOKA, Kazunori SATO, Shuichi ONO, Ryoi GOTO, Tachio SATO, Hiroshi FUKUDA |
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| Authors(kana) | |
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| Organization | Department of Nuclear Medicine and Radiology, IDAC, Tohoku University |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 33 |
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| Number | 1 |
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| Page | 69-72 |
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| Year/Month | 1996/1 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]A Single photon emitter labeled tracer, 99mTc-ethyl cysteinate dimer (99mTc-ECD), has now been used for rCBF studies with SPECT. However, normal distribution pattern of this agent in the brain still remains unclear. Therefore, the specific purpose of this study was to investigate the normal distribution pattern of 99mTc-ECD SPECT image. Regional cerebral distribution was measured with SPECT and 984+-17 MBq of 99mTc-ECD in ten normal subjects. During the SPECT measurement, subjects were placed comfortably in a supine position with their eyes closed. Each SPECT image was anatomically standardized using a computerized brain atlas system of Roland et al. (HBA : Human Brain Atlas) and X-CT image. Anatomically standardized SPECT images were globally normalized to 100 count/voxel. Then, the mean and SD images of brain SPECT were calculated voxel-by-voxel basis. The highest radioactivity was found in the medial aspect of the occipital lobe. The results indicate that the normal distribution pattern of 99mTc-ECD in the human brain may be not simply reflect the regional cerebral blood flow. |
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| Practice | Clinical medicine |
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| Keywords | 99mTc-ECD, SPECT, Human brain, Cerebral perfusion, Anatomical standardization. |
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