| Japanese |
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| Title | 早期Alzheimer病患者のベンゾジアゼピン受容体と脳血流についての検討 - 123I-イオマゼニルと123I-IMPによるSPECTを用いて - |
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| Subtitle | 原著 |
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| Authors | 北村伸*, 越泰彦*, 小宮山佐*, 酒寄修*, 駒場祐一*, 大山雅史*, 津金澤俊和*, 三品雅洋*, 赫彰郎* |
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| Organization | *日本医科大学付属第一病院第二内科 |
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| Journal | 核医学 |
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| Volume | 33 |
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| Number | 1 |
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| Page | 49-56 |
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| Year/Month | 1996/1 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」123I-イオマゼニル(IMZ)と123I−IMPのSPECTにより, 早期のAlzheimer病(AD)患者のベンゾジアゼピン受容体(BZR)と脳血流量(CBF)について, 一側性脳梗塞患者の非病巣側の値を対照として検討した. 早期のADでは, 前頭葉皮質と頭頂葉皮質のCBF(対小脳比)は対照群より低下していたが, IMZ後期像の放射能(対小脳比)とwashout(IMZ後期像/早期像放射能比, L/E比)については差がなかった. しかし, 痴呆症状が進行した例では, IMZ後期像での対小脳比とL/E比は大脳皮質で低下していた. HDS-R, MMSで評価した知的機能とIMZ後期像における対小脳比の間に有意な相関がみられた. 以上の結果から, ADの早期では, 皮質のBZRはCBFに比して保たれており, CBFの低下は神経細胞の減少によるのではなく神経機能の低下によることが示唆された. IMZによるBZRの検討はADの病態把握, 重症度および知的機能の評価に有用な情報をもたらすことが示された. |
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| Practice | 臨床医学：一般 |
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| Keywords | 123I-iomazenil, Benzodiazepine receptors, Alzheimer's disease, SPECT, Cerebral blood flow. |
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| English |
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| Title | Benzodiazepine Receptor and Cerebral Blood Flow in Early Alzheimer's Disease - SPECT Study Using 123I-Iomazenil and 123I-IMP - |
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| Authors | Shin KITAMURA, Yasuhiko KOSHI, Tasuku KOMIYAMA, Osamu SAKAYORI, Yuichi KOMABA, Masashi OHYAMA, Masahiro MISHINA, Toshikazu TSUGANESAWA, Akiro TERASHI |
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| Organization | Second Department of Internal Medicine, Nippon Medical School First Hopital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 33 |
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| Number | 1 |
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| Page | 49-56 |
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| Year/Month | 1996/1 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]This study was designed to investigate benzodiazepine receptors(BZR) and cerebral blood flow (CBF) in patients with early Alzheimer's disease. Imaging of BZR and measurement of CBF were performed by SPECT using 123I-Iomazenil (IMZ) and 123I-IMP respectively, in seven patients with early Alzheimer's disease and five patients with unilateral left cerebral infarction as controls. The values for the normal cerebral hemisphere (raito to the contralateral cerebellum) in patients with cerebral infarction were adopted as control values. In patients with Alzheimer's disease, the CBF (ratio to cerebellum) decreased significantly in the frontal cortex and the parietal cortex compared with the control values. There was no significant difference in late IMZ SPECT counts (ratio to cerebellum) and washout (the ratio of late-to-early IMZ SPECT counts) between patients with Alzheimer's disease and the controls. However, the late IMZ SPECT counts and washout decreased in one patient with moderate dementia. There was a significant correlation between the severity of dementia and the late IMZ SPECT counts in the temporal cortex and the parietal cortex. These results suggest that benzodiazepine binding sites are relatively well preserved in patients with early Alzheimer's disease, and reduction of the CBF is caused by neuronal dysfunction rather than by neuronal loss. IMZ SPECT study is useful and necessary for clarifying the pathophysiological state in Alzheimer's disease. |
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| Practice | Clinical medicine |
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| Keywords | 123I-iomazenil, Benzodiazepine receptors, Alzheimer's disease, SPECT, Cerebral blood flow. |
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