| Japanese |
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| Title | 123I-BMIPP心筋SPECTを用いた拡張型心筋症におけるCoenzyme Q10投与による治療効果の判定 - 大阪大学グループ多施設共同研究 - |
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| Subtitle | 原著 |
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| Authors | 西村恒彦*, 堀正二** |
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| Organization | *大阪大学医学部トレーサ情報解析, **第一内科 |
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| Journal | 核医学 |
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| Volume | 33 |
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| Number | 1 |
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| Page | 27-32 |
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| Year/Month | 1996/1 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」拡張型心筋症15例を対象として心筋ミトコンドリア機能障害を改善するとされているCoenzyme Q10(CoQ10) 30mg/dayを2〜4週間投与前後に123I-BMIPP心筋SPECTを用いて心筋脂肪酸代謝の改善が認められるか検討した. 123I-BMIPP心筋SPECT像から短軸3断層面および長軸1断層面を選び, 25セグメントに分別した. 次いで, 各セグメントを4段階のスコアとし, 全スコアの総和をBMIPP defect scoreとした. CoQ10投与前後におけるBMIPP defect scoreは投与時7.7±6.1, 非投与時12.7±7.4とCoQ10投与にて改善を示した. 123I-BMIPP心筋SPECTおよび心エコー図を同時に施行した8症例においてBMIPP defect scoreは投与時10.8±7.2, 非投与時16.1±8.2とCoQ投与にて改善した. 一方, 心エコー図から求めた%FSは, 投与時21.3±8.2%, 非投与時21.2±10.8%と有意差を認めなかった. 拡張型心筋症において心筋脂肪酸代謝イメージングを用いてCoQ10による治療効果の判定が鋭敏に行えることが示された. |
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| Practice | 臨床医学：一般 |
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| Keywords | 123I-BMIPP, Coenzyme Q10, Dilated cardiomyopathy. |
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| English |
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| Title | Therapeutic Effects of Coenzyme Q10 on Dilated Cardiomyopathy : Assessment by 123I-BMIPP Myocardial Single Photon Emission Computed Tomography (SPECT) : A Multicenter Trial in Osaka University Medical School Group |
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| Authors | Tsunehiko NISHIMURA*, Masatsugu HORI** |
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| Organization | *~Tracer Kinetics and Nuclear Medicine, **First Department of Internal Medicine, Osaka University, Medical School |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 33 |
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| Number | 1 |
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| Page | 27-32 |
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| Year/Month | 1996/1 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]To evaluate therapeutic effects of Cenzyme Q10(CoQ10), 15 patients with dilated cardiomyopathy were investigated by 123I-BMIPP myocardial single photon emission computed tomography(SPECT). The BMIPP defect score was determined semiquantitatively by using representative short and long axial SPECT images. Mean BMIPP defect score with CoQ10 treatment was significantly low, 7.7+-6.1 compared to 12.7+-7.4 without CoQ10 treatment. On the other hand, in 8 patients of dilated cardiomyopathy, % fractional shortening using echocardiography was not different before and after CoQ10 treatment. In conclusion, 123I-BMIPP myocardial SPECT was proved to be sensitive to evaluate the therapeutic effects of CoQ10, which improve myocardial mitochondrial function, in the cases of dilated cardiomyopathy. |
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| Practice | Clinical medicine |
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| Keywords | 123I-BMIPP, Coenzyme Q10, Dilated cardiomyopathy. |
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