| Japanese |
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| Title | 99mTc-MIBIを用いた負荷 - 安静心電図同期SPECT 1日法の有用性についての検討 |
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| Subtitle | 原著 |
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| Authors | 野澤真人*, 玉木長良***, 杉原秀樹*, 稲本康彦*, 谷口義光**, 青木悦雄**, 古市健治**, 三ッ浪健一****, 木之下正彦**** |
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| Authors(kana) | |
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| Organization | *公立高島総合病院内科, **放射線科, ***京都大学医学部核医学科, ****滋賀医科大学第一内科 |
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| Journal | 核医学 |
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| Volume | 32 |
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| Number | 12 |
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| Page | 1363-1368 |
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| Year/Month | 1995/12 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」99mTc-MIBIを用いた負荷 - 安静心電図同期SPECT 1日法を虚血性心疾患の疑われた110例に施行し, 虚血性心疾患診断における有用性とその予後について検討した. 負荷はトレッドミルによる多段階負荷を行い, 最大負荷時99mTc-MIBI 250 MBqを静注し, 一時間後負荷時非同期SPECT像の撮影を行った. 撮像後ただちに画像を処理し読影を行いNormal, Equivocal, Abnormalの三段階に判定した. Nomal(n=53)は負荷のみで検査を終了した. Equivocal(n=20), Abnormal(n=37)例は安静時99mTc-MIBI 750 MBqを静注し, 安静時心電図同期SPECT像撮影を行った. Equivocal 20例中16例は負荷時と安静時の血流画像で差異は認められず, また壁運動でも全例において異常なく, 正常例と考えられた. Abnormal 37例中12例において安静時画像で改善が認められ, 25例では改善は認められなかった. 平均8.5か月の予後の評価ではAbnormal例では心事故の件数が多く, 特に安静時血流分布像にて改善が認められ虚血が疑われた症例では死亡例が2例あった. 反対にNormal例の予後は良好であった. 本法は負荷時血流画像にて異常の認められない症例では負荷時のみで検査を終了でき, また1日で検査を終了できる. さらに壁運動所見も得られ, 虚血性心疾患のスクリーニング検査法として有用と考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | Emission computed tomography, 99mTc-MIBI, Coronary artery disease, Wall motion, Myocardial perfusion. |
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| English |
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| Title | Value of Stress-Rest ECG Gated SPECT One Day Protocol Using 99mTC-MIBI |
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| Authors | Masato NOZAWA*, Nagara TAMAKI***, Hideki SUGIHARA*, Yasuhiko INAMOTO*, Yoshimitsu TANIGUCHI**, Etsuo AOKI**, Kenji FURUICHI**, Kenichi MITSUNAMI****, Masahiko KINOSHITA**** |
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| Authors(kana) | |
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| Organization | *Department of Medicine, **Department of Radiology, Takashima General Hospital, ***Department of Nuclear Medicine, Kyoto University Faculty of Medicine, ****First Department of Internal Medicine, Shiga University of Medical Science |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 32 |
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| Number | 12 |
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| Page | 1363-1368 |
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| Year/Month | 1995/12 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]A total of 110 patients suspected with CAD who had symptoms or ECG abnormalities were enrolled in the stress-rest ECG gated SPECT one day protocol using 99mTc-MIBI. All the patients underwent symptomlimited exercise testing and 250 MBq of MIBI was injected at peak exercise. Exercise perfusion SPECT images were reviewed by two trained doctors to classify into three groups ; normal, equivocal and abnormal. Patients with normal stress image (n=53) did not receive the resting study. On the other hand, those with equivocal (n=20) and abnormal (n=37) stress images performed resting study, including gated SPECT. Of 20 equivocal cases, 16 patients showed unchanged resting perfusion. All of these had normal wall motion. The remaining 4 patients showed improved resting perfusion, indicating presence of myocardial ischemia. Of 37 abnormal cases, 12 patients showed improved resting perfusion, whereas 25 patients showed unchanged resting perfusion. Cardiac events were more often observed in abnormal cases, especially those associated with myocardial ischemia, while good prognosis was obtained in normal cases. Values of this protocol are (1) Patients with normal stress images need no resting study. (2) All the procedure can be completed in one day. (3) Both cardiac function and perfusion can be obtained with gated SPECT. These data indicates that this protocol is valuable for screening patients suspected with CAD. |
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| Practice | Clinical medicine |
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| Keywords | Emission computed tomography, 99mTc-MIBI, Coronary artery disease, Wall motion, Myocardial perfusion. |
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