| Japanese |
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| Title | MRIで梗塞や出血を認めないモヤモヤ病患者の脳循環代謝 |
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| Subtitle | 原著 |
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| Authors | 桑原康雄*, 一矢有一*, 佐々木雅之*, 吉田毅*, 赤司祐子*, 福村利光*, 増田康治*, 松島俊夫**, 福井仁士** |
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| Authors(kana) | |
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| Organization | *九州大学医学部放射線科, **脳神経外科 |
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| Journal | 核医学 |
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| Volume | 32 |
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| Number | 12 |
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| Page | 1355-1362 |
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| Year/Month | 1995/12 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」MRIで脳実質に梗塞や出血などの異常を認めなかった15歳から47歳までのモヤモヤ病患者5例を対象に脳循環代謝を測定した. 脳血流量, 酸素摂取率, 酸素消費量は健常群とモヤモヤ病群で差がなかった. 血液量はモヤモヤ病群の大脳皮質および線条体で増加していたが, 小脳では差がなかった. 通過時間は前頭葉と頭頂葉で有意に低下していた. 脳血管CO2反応性は前頭葉, 側頭葉, 頭頂葉で著明に低下していたが, 後頭葉, 視床および小脳では比較的保たれていた. 以上, 形態学的には脳実質に異常のみられない症例においてもモヤモヤ病では脳循環予備能は明らかに低下しており, 患者管理や治療方針を決める上で考慮すべき点と考えられた. 「I. はじめに」モヤモヤ病は両側内頸動脈の進行性狭窄と側副血行路の形成を特徴とし, 慢性に経過する疾患である. 本症では経過中に梗塞や出血を起こす頻度が高いことが知られており, 特に, 小児期に発症するものは脳虚血や梗塞による発作を繰り返し, 脳に障害をきたすものが多いといわれている. |
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| Practice | 臨床医学：一般 |
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| Keywords | Positron emission CT, MRI, Cerebrovascular CO2 response, Cerebral blood flow, Moyamoya disease. |
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| English |
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| Title | Cerebral Hemodynamics and Metabolism in Patients with Moyamoya Disease Not Demonstrating Either Cerebral Infarct or Hemorrhage on MRI |
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| Authors | Yasuo KUWABARA*, Yuichi ICHIYA*, Masayuki SASAKI*, Yuko AKASHI*, Tsuyoshi YOSHIDA*, Toshimitsu FUKUMURA*, Kouji MASUDA*, Toshio MATSUSHIMA**, Masashi FUKUI** |
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| Authors(kana) | |
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| Organization | *Department of Radiology, **Department of Neurosurgery, Kyushu University of Faculty of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 32 |
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| Number | 12 |
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| Page | 1355-1362 |
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| Year/Month | 1995/12 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]We evaluated the cerebral hemodynamics and metabolism in Moyamoya patients who did not demonstrate either cerebral infarct or hemorrhage on MRI. The subjects consisted of 5 patients with Moyamoya disease (4 females and one male, aged from 15 to 40 years). The CBF, OEF and CMRO2 of the Moyamoya patients did not differ from those of the normal control subjects. The CBV did increase significantly in the cerebral cortices and striatum, but not in the cerebellum. The TT was also significantly prolonged in the frontal and parietal regions. The cerebrovascular CO2 response was markedly impaired in the frontal, temporal and parietal cortices. However, it was relatively preserved in the occipital cortex, thalamus and cerebellum. Thus, the cerebral hemodynamic reserve capacity decreased even in the Moyamoya patients not demonstrating either cerebral infarct or hemorrhage on MRI, and it should be considered in the management of these patients. |
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| Practice | Clinical medicine |
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| Keywords | Positron emission CT, MRI, Cerebrovascular CO2 response, Cerebral blood flow, Moyamoya disease. |
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